Direct Oral Anticoagulant- or Warfarin-Related Major Bleeding

Direct oral anticoagulants (DOACs) have expanded the armamentarium for antithrombotic therapy. Although DOAC-related major bleeding was associated with favorable outcomes compared with warfarin in clinical trials, warfarin effects were reversed in < 40% of cases, raising concerns about the generalizability of this finding.Consecutive patients ≥ 66 years presented to five tertiary care hospitals across three cities in Ontario, Canada from October...