Abstract null null Background null Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease associated with significant morbidity and mortality. Nintedanib and pirfenidone are two antifibrotic medications currently approved for slowing the rate of lung function decline in IPF, but information on treatment effect on mortality and risk of acute exacerbation (AE) remains limited or unknown. null null null Research Question null Does antifibrotic treatment decrease ri...
Last. Klaus Kenn(University of Marburg)H-Index: 17
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ABSTRACT null null Background null During exercise, dynamic hyperinflation (DH), measured by a reduction in inspiratory capacity (IC), increases exertional dyspnoea and reduces functional capacity in many patients with severe COPD. While non-invasive ventilation (NIV) during exercise can improve exercise duration, the effect on DH is unclear. null null null Research Questions null In people with COPD, resting hyperinflation, and evidence of DH during exercise: 1) does bilevel NIV during exercise...
#2Jonathan G. Goldin(UCLA: University of California, Los Angeles)H-Index: 69
Last. Tamera J. Corte(RPA: Royal Prince Alfred Hospital)H-Index: 31
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Abstract null null Background null Interstitial lung abnormalities (ILA) may represent undiagnosed early-stage or subclinical interstitial lung disease (ILD). ILA are often observed incidentally in patients who subsequently develop clinically overt ILD. There is limited information on consensus definitions for, and the appropriate evaluation of, ILA; early recognition of patients with ILD remains challenging, yet critically important. Expert consensus could inform early recognition and referral....
#1Tsuyoshi Takahashi(WashU: Washington University in St. Louis)H-Index: 5
#2Yuriko Terada(WashU: Washington University in St. Louis)H-Index: 4
Last. Bryan F. Meyers(WashU: Washington University in St. Louis)H-Index: 70
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Abstract null null Background null Combined pulmonary fibrosis and emphysema (CPFE) is recognized as a characteristic syndrome of smoking-related interstitial lung disease that has a worse prognosis than idiopathic pulmonary fibrosis (IPF). However, outcomes after lung transplantation for CPFE have not been reported. The aim of this study is to describe the clinical features and outcomes of CPFE after lung transplantation. null null null Research question null What are the clinical features and ...
BACKGROUND Recent medical society opinions have questioned the use of early antimicrobials in patients with sepsis, but without septic shock. RESEARCH QUESTION Is time from Emergency Department (ED) presentation to administration of antibiotics associated with progression to septic shock among patients presenting with suspected infection? STUDY DESIGN and Methods: This was a retrospective cohort study from March 2007 to March 2020. All adults with suspected infection and first antimicrobial admi...
#2Chad A. Newton(UTSW: University of Texas Southwestern Medical Center)H-Index: 8
Abstract null null Pulmonary fibrosis comprises a wide range of fibrotic lung diseases with unknown pathogenesis and poor prognosis. Familial pulmonary fibrosis (FPF) represents a unique subgroup of patients in which at least one other relative is also affected. Patients with FPF exhibit a wide range of pulmonary fibrosis phenotypes, although idiopathic pulmonary fibrosis is the most common subtype. Despite variable disease manifestations, FPF patients experience worse survival compared to their...
Abstract null null Background null Despite increasing awareness of swimming-induced pulmonary edema (SIPE), there is a lack of large population-based studies and the incidence is unknown. null null null Research question null What is the incidence of SIPE in a mixed group of competitive and recreational swimmers during a large open water swimming event? null null null Methods null In four consecutive years (2016-2019), a prospective cohort study was conducted during Sweden’s largest open water s...
Abstract null null Background null Although multiple risk factors for development of pneumonia in patients with trauma sustained in a motor vehicle accident have been studied, the effect of prehospital time on pneumonia incidence post-trauma is unknown. null null null Research Question null Is prolonged prehospital time an independent risk factor for pneumonia? null null null Study Design and Methods null : We retrospectively analyzed prospectively collected clinical data from 806,012 motor vehi...
BACKGROUND The coping styles of the Sickness Insight in Coping Questionnaire (SICQ; positivism, redefinition, toughness, fighting spirit, non-acceptance) may affect the health and recovery of hospitalized critically ill patients. RESEARCH QUESTION Do the SICQ coping styles of hospitalized critically ill patients relate to the patients´ health-related quality of life (HRQoL) and recovery? STUDY DESIGN AND METHODS A prospective cohort study was conducted in a single university-affiliated Dutch hos...