Original paper

Genetic Otx2 mis-localization delays critical period plasticity across brain regions

Volume: 22, Issue: 5, Pages: 680 - 688
Published: Feb 14, 2017
Abstract
Accumulation of non-cell autonomous Otx2 homeoprotein in postnatal mouse visual cortex (V1) has been implicated in both the onset and closure of critical period (CP) plasticity. Here, we show that a genetic point mutation in the glycosaminoglycan recognition motif of Otx2 broadly delays the maturation of pivotal parvalbumin-positive (PV+) interneurons not only in V1 but also in the primary auditory (A1) and medial prefrontal cortex (mPFC)....
Paper Details
Title
Genetic Otx2 mis-localization delays critical period plasticity across brain regions
Published Date
Feb 14, 2017
Volume
22
Issue
5
Pages
680 - 688
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