Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations
Volume: 214, Issue: 3, Pages: 569 - 578
Published: Feb 16, 2017
Abstract
Activation of extrasynaptic N-methyl-d-aspartate (NMDA) receptors causes neurodegeneration and cell death. The disease mechanism involves a pathological triad consisting of mitochondrial dysfunction, loss of integrity of neuronal structures and connectivity, and disruption of excitation–transcription coupling caused by CREB (cyclic adenosine monophosphate–responsive element-binding protein) shut-off and nuclear accumulation of class IIa histone...
Paper Details
Title
Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations
Published Date
Feb 16, 2017
Volume
214
Issue
3
Pages
569 - 578
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