Retinal Architecture and Melanopsin-Mediated Pupillary Response Characteristics

Importance

A neurophysiologic signature of the melanopsin-mediated persistent constriction phase of the pupillary light reflex may represent a surrogate biomarker for the integrity of the retinohypothalamic tract, with potential utility for investigating alterations in homeostatic mechanisms associated with brain disorders and implications for identifying new treatments.

Objective

To characterize abnormalities of retinal...