Importance Severe forms of Tourette syndrome or chronic tic disorder (TS/CTD) may involve repeated head jerking. Isolated case reports have described a spectrum of severe neck disorders in individuals with TS/CTD. However, the nature and prevalence of cervical spine disorders in TS/CTD are unknown. Objective To establish if TS/CTD are associated with an increased risk of cervical spine disorders and related neurological complications compared with individuals from the general population. Design,...
Last. Dena B. Dubal(UCSF: University of California, San Francisco)H-Index: 28
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Importance null The X chromosome represents 5% of the human genome in women and men, and its influence on cognitive aging and Alzheimer disease (AD) is largely unknown. null Objective null To determine whether the X chromosome is associated with sex-specific cognitive change and tau pathology in aging and AD. null Design, Setting, Participants null This study examined differential gene expression profiling of the X chromosome from an RNA sequencing data set of the dorsolateral prefrontal cortex ...
#2Melinda Magyari(Copenhagen University Hospital)H-Index: 19
Last. Jan Lycke(Sahlgrenska University Hospital)H-Index: 45
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Importance null Treatment strategies for relapsing-remitting multiple sclerosis (RRMS) vary markedly between Denmark and Sweden. The difference in the association of these national strategies with clinical outcomes is unknown. null Objective null To investigate the association of national differences in disease-modifying treatment (DMT) strategies for RRMS with disability outcomes. null Design, Setting, and Participants null This cohort study used data on 4861 patients from the Danish and Swedis...
Importance Endovascular therapy (EVT) improves functional outcomes in acute ischemic stroke (AIS) with large vessel occlusion (LVO). Whether implementation of a regional prehospital transport policy for comprehensive stroke center triage increases use of EVT is uncertain. Objective To evaluate the association of a regional prehospital transport policy that directly triages patients with suspected LVO stroke to the nearest comprehensive stroke center with rates of EVT. Design, Setting, and Partic...
Importance null One in 3 adults experiences clinically significant symptoms of depression during the first year after a stroke, but evidence to support the use of antidepressants in this population remains scant. null Objective null To investigate whether daily treatment with 20 mg of fluoxetine hydrochloride reduces the proportion of people affected by clinically significant symptoms of depression after stroke. null Design, Setting, and Participants null In this secondary analysis of the Assess...