Elliot M. Frohman
University of Texas at Austin
OphthalmologyInternal medicineSurgeryPathologyPsychologyNeurologyNeuroscienceImmunologyOptic neuritisRetinaVisual acuityOptical coherence tomographyDiseaseNerve fiber layerMultiple sclerosisRetinalOptic nerveNatalizumabMedicineBiology
371Publications
84H-index
17.1kCitations
Publications 366
Newest
#3Thomas C. Varkey (KP: Kaiser Permanente)H-Index: 2
#4Robert P. Lisak (KP: Kaiser Permanente)H-Index: 1
Last. Scott Newsome (KP: Kaiser Permanente)H-Index: 1
view all 10 authors...
A 31-year-old woman presented with fever, ataxia, double vision, confusion, and auditory hallucinations, preceded by 2 weeks of cough, increased oral secretions, and dermatomal rash. Her medical history was unremarkable. Her family history was notable for first-degree relatives with autoimmune
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#2Nick Hogan (University of Texas at Austin)H-Index: 1
Last. Teresa C. FrohmanH-Index: 37
view all 18 authors...
The patient is a right-handed White woman with relapsing-remitting MS diagnosed subsequent to left acute optic neuritis (AON). She described a previous transient episode of severe, electrical, and paroxysmal facial pain consistent with trigeminal neuralgia. Initial MRI demonstrated supratentorial
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Objective To determine whether the punctuated administration of low-dose rituximab, temporally linked to B-cell hyperrepopulation (defined when the return of CD19+ B cells approximates 40%–50% of baseline levels as measured before alemtuzumab treatment inception), can mitigate alemtuzumab-associated secondary autoimmunity. Methods In this hypothesis-driven pilot study, 10 patients received low-dose rituximab (50–150 mg/m2), a chimeric anti-CD20 monoclonal antibody, after either their first or se...
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#1Cole Maguire (UCSF: University of California, San Francisco)H-Index: 1
#2Teresa Frohman (UCSF: University of California, San Francisco)H-Index: 1
Last. Esther Melamed (UCSF: University of California, San Francisco)H-Index: 9
view all 5 authors...
In the unprecedented pandemic of the coronavirus disease 2019 (COVID-19) along with a limited clinical understanding on effective vaccines and therapies, there are currently many unknowns for patients with autoimmune conditions, such as MS, who require ongoing treatment with immunotherapies. As information is currently lacking on the immune effects of COVID-19 in the context of MS disease-modifying therapies (DMTs), a challenging clinical question being faced by patients and neurologists is whet...
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#1Elliot M. Frohman (University of Texas at Austin)H-Index: 84
#2Nicole R. Villemarette-Pittman (LSU Health Sciences Center New Orleans)H-Index: 14
Last. Teresa C. Frohman (University of Texas at Austin)H-Index: 37
view all 10 authors...
Abstract Here, in Part II of a duology on the characterization and potential treatment for COVID-19, we characterize the application of an innovative treatment regimen for the prevention of the transition from mild to severe COVID-19, as well as detail an intensive immunotherapy intervention hypothesis. We propose as a putative randomized controlled trial that high-dose methotrexate with leucovorin (HDMTX-LR) rescue can abolish ‘PANIC’, thereby ‘left-shifting’ severe COVID-19 patients to the gro...
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#1Elliot M. Frohman (University of Texas at Austin)H-Index: 84
#2Nicole R. Villemarette-Pittman (LSU Health Sciences Center New Orleans)H-Index: 14
Last. Teresa C. Frohman (University of Texas at Austin)H-Index: 37
view all 9 authors...
Abstract The COVID-19 pandemic has produced a world-wide collapse of social and economic infrastructure, as well as constraining our freedom of movement. This respiratory tract infection is unprecedented in that it targets the most distal and highly vulnerable aspect of the human bronchopulmonary tree, specifically, the alveoli that are responsible for the loading of oxygen upon red cell hemoglobin for use by all of the body's tissues. In most symptomatic individuals, the reaction is a productiv...
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#1Olwen C. Murphy (Johns Hopkins University)H-Index: 9
#2Ohemaa Kwakyi (Johns Hopkins University)H-Index: 7
Last. Shiv Saidha (Johns Hopkins University)H-Index: 28
view all 21 authors...
Background:The retinal vasculature may be altered in multiple sclerosis (MS), potentially acting as a biomarker of disease processes.Objective:To compare retinal vascular plexus densities in people...
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#2Alissa Rothman (NYU: New York University)H-Index: 1
#3Natalia L. Gonzalez (University of Texas at Austin)H-Index: 3
Background:Optical coherence tomography (OCT) measurements of ganglion cell + inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thicknesses are associated with visual function (VF) and disability in multiple sclerosis (MS). However, the value of measuring Bruch membra
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#1Christopher Perrone (UPenn: University of Pennsylvania)H-Index: 3
#2Robert P. LisakH-Index: 66
Last. Teresa C. FrohmanH-Index: 37
view all 17 authors...
A 54-year-old woman presented with complaints of myalgias, fatigue, and progressive leg weakness of several weeks duration, followed by acute loss of vision in her left eye. Her medical history was notable for long-standing systemic lupus erythematosus (SLE) that was actively treated with prednisone, mycophenolate mofetil, and quinacrine. The National Multiple Sclerosis Society Case Conference Proceedings are both a live educational Webinar, in conjunction with a peer review publishing initiativ...
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#1Rachel Nolan-Kenney (NYU: New York University)H-Index: 4
#2Mengling Liu (NYU: New York University)H-Index: 1
Last. Laura J. Balcer (NYU: New York University)H-Index: 77
view all 26 authors...
Objective: To determine the optimal thresholds for intereye differences in retinal nerve fiber and ganglion cell + inner plexiform layer thicknesses for identifying unilateral optic nerve lesions in multiple sclerosis. Current international diagnostic criteria for multiple sclerosis do not include the optic nerve as a lesion site despite frequent involvement. Optical coherence tomography detects retinal thinning associated with optic nerve lesions. Methods: In this multicenter international stud...
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