Germline and somatic DICER1 mutations in familial and sporadic liver tumors
Abstract
Growing evidence suggests that genetic predisposition significantly increases the risk of hepatocellular carcinoma (HCC), independently from the presence of other risk factors. Here, we report a novel germline DICER1 mutation associated with familial recurrent liver tumors. We then aimed to investigate the contribution of constitutional and somatic DICER1 mutations on HCC occurrence.We investigated two individuals of a single family that...
Paper Details
Title
Germline and somatic DICER1 mutations in familial and sporadic liver tumors
Published Date
Apr 1, 2017
Journal
Volume
66
Issue
4
Pages
734 - 742
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Notes
History