Last. Liang Qiao(USYD: University of Sydney)H-Index: 35
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Abstract Fatty liver disease associated with metabolic dysfunction is of increasing concern in mainland China, the world's most populous country. The incidence of fatty liver disease is highest in China, surpassing the incidence in European countries and the USA. An international consensus panel recently published an influential report recommending a novel definition of fatty liver disease associated with metabolic dysfunction. This recommendation includes a switch in name from nonalcoholic fatt...
#1Zhou Huichao(SYSU: Sun Yat-sen University)H-Index: 1
#2Chu‐Xing Liu(SYSU: Sun Yat-sen University)H-Index: 1
Last. Shi-Mei Zhuang(SYSU: Sun Yat-sen University)H-Index: 37
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Abstract Background & Aims Contradictory roles of the androgen receptor (AR) in hepatocellular carcinoma (HCC) metastasis have been reported. We have shown that VETC ( v essels e ncapsulating t umor c lusters) mediates invasion-independent metastasis, whereas VETC- HCCs metastasize in an invasion-dependent manner. Here we aimed to reveal the roles of AR in HCC metastasis. Methods Mouse xenograft models, clinical samples, and cell models were used. Results AR expression was significantly lower in...
Last. Stefan Wieland(University Hospital of Basel)H-Index: 7
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Abstract Background & Aims Loss of serum hepatitis B surface antigen (HBsAg) is a hallmark of spontaneous and therapy induced resolution of HBV infection, since it generally reflects a profound decrease in viral replication. However, integrated HBV DNA can contribute to HBsAg expression independent of viral replication. The relative contributions of these two sources of HBsAg are not well understood. Specifically, it is not known whether actively transcribed HBV integration could spread througho...
Last. Josep M. Llovet(Catalan Institution for Research and Advanced Studies)H-Index: 108
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Abstract Background and Aims Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We aimed to identify unique molecular traits characterizing NASH-HCC compared to other HCC aetiologies. Methods We collected 80 NASH-HCC and 125 NASH samples from 5 institutions. Expression array (n=53 NASH-HCC; n=74 NASH) and whole exome sequencing (n=52 NASH-HCC) data were compared to HCCs of other aetiologies (n=184)....
Abstract Background and aim There is uncertainty on the risk of dying after coronavirus disease 2019 (Covid-19) in chronic liver disease patients. Patients and methods We explored the outcomes of all Covid-19 adult inpatients in France, in 2020. We computed adjusted odds-ratios to measure the associations between chronic liver disease, alcohol use disorders, mechanical ventilation and day-30, in-hospital, mortality. Results The sample comprised 259,110 patients [median (interquartile range) age ...
ABSTRACT Background and Aims COVID-19 is associated with liver injury and elevated IL-6. We hypothesized that IL-6 trans-signaling in liver sinusoidal endothelial cells (LSECs) leads to endotheliopathy (a proinflammatory and procoagulant state) and liver injury in COVID-19. Methods Coagulopathy, endotheliopathy, and ALT were retrospectively analyzed in a subset (n=68), followed by a larger cohort(n=3,780) of COVID-19 patients. Liver histology from 43 COVID-19 patients was analyzed for endothelio...
Abstract Background and Aims Vibration-controlled transient elastography (VCTE), point shear wave elastography (pSWE), two-dimensional shear wave elastography (2DSWE), magnetic resonance elastography (MRE), and magnetic resonance imaging (MRI) are proposed as non-invasive tests for patients with non-alcoholic fatty liver disease (NAFLD). This study evaluated their diagnostic accuracy for liver fibrosis and non-alcoholic steatohepatitis (NASH). Methods PubMED/MEDLINE, EMBASE and the Cochrane Libr...