ABSTRACT Background and Aims Liver transplantation (LT) has been proposed to be an effective salvage therapy even for the sickest patients with acute-on-chronic liver failure (ACLF). This large collaborative study was designed to address the current clinical practice and outcomes of ACLF patients wait listed (WL) for LT in Europe. Methods Retrospective study including 308 consecutive ACLF patients, listed in 20 centres across 8 European countries, from January 2018 to June 2019. Results 2677 pat...
#1Jens Ricke(LMU: Ludwig Maximilian University of Munich)H-Index: 54
#2Regina Schinner(LMU: Ludwig Maximilian University of Munich)H-Index: 6
Last. Enrico N. De Toni(LMU: Ludwig Maximilian University of Munich)H-Index: 23
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ABSTRACT null Background & Aims null SORAMIC is a previously published randomized controlled trial assessing survival in patients with advanced hepatocellular carcinoma (HCC) receiving sorafenib with or without selective internal radiation therapy (SIRT). Based on the per-protocol population (PP), we assessed whether the outcome of patients receiving SIRT+sorafenib vs. sorafenib alone was affected by adverse effects of SIRT on liver function. null Methods null The PP population consisted of 109 ...
Abstract null Background & Aims null Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder with non-alcoholic steatohepatitis (NASH) being a more progressive phenotype associated with progression to cirrhosis. Type III collagen is a main component of the fibrotic extracellular matrix. PRO-C3 is a biomarker for detectison of moderate/severe fibrosis and the test is further improved when incorporated into the ADAPT algorithm. Here, we validated PRO-C3 and ADAPT within the CENTAUR sc...
#1Paul J. Thuluvath(Mercy Medical Center (Baltimore, Maryland))H-Index: 14
#2Polly Robarts(Mercy Medical Center (Baltimore, Maryland))
Last. Mahak Chauhan(Mercy Medical Center (Baltimore, Maryland))
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Abstract null Background &Aims null Liver transplant (LT) recipients or other immunocompromised patients were not included in the registration trials of vaccine studies against SARS-CoV-2. Although clinical efficacy of COVID vaccines in immunocompromised patients was unknown, many societies had recommended vaccination of this highly vulnerable patient population. null Methods null In this prospective study, we determined antibody (Ab) response to spike protein, 4 weeks after the 2nd dose of mRNA...
Last. Anna S. Lok(UM: University of Michigan)H-Index: 59
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Abstract null Hepatic encephalopathy (HE) is a complication of cirrhosis characterized by neuropsychiatric and motor dysfunction. Microbiota-host interactions have an important role in HE pathogenesis. Therapies targeting microbial community composition and function have been explored for the treatment of HE. Prebiotics, probiotics and fecal microbiota transplant (FMT) have aimed to increase the abundance of potentially beneficial taxa, while antibiotics have aimed to decrease the abundance of p...
Abstract null Background and Aims null Messenger RNA (mRNA)-based therapeutics are rapidly progressing to the clinic and hold tremendous potential for benefiting millions of people worldwide. Therapeutic targeting of injuries that require transient restoration of proteins by mRNA delivery is an attractive aspect, however until recently, it has remained poorly explored. In this study, we examined for the first time, the therapeutic utility of mRNA delivery in liver fibrosis and cirrhosis, which c...
Abstract-Summary null NAFLD is projected to become the leading cause of HCC in many countries. Many risk factors for NAFLD are also independently associated with HCC, including obesity, diabetes, Hispanic ethnicity and genetic polymorphisms in PNPLA3, TM6SF2, GCKR, MBOAT7 and HSD17B13. Steatosis-related lipotoxicity and oxidative DNA damage can induce hepatocarcinogenesis. These factors may explain the association between NAFLD and HCC, especially in the absence of cirrhosis. In fact, NAFLD/NASH...
Abstract null null Background&aims null Patients with acute decompensation (AD) of cirrhosis progressing to acute-on-chronic liver failure (ACLF) present a systemic hyperinflammatory response associated with increased circulating levels of small-molecule metabolites. To investigate whether these alterations reflect inadequate cell energy output, we assessed mitochondrial morphology and central metabolic pathways with emphasis on the tricarboxylic acid (TCA) cycle in peripheral leukocytes from AD...