Analytical Methods for Determining Third and Fourth Generation Fluoroquinolones: A Review

Fluoroquinolones of the third and fourth generation posses wide bactericidal activity. Monitoring concentrations of antibacterial agents provides effective therapy and prevents the increase of bacterial resistance to antibiotics. The pharmacodynamic parameters that best describe fluoroquinalone activity are AUC/MIC and C max/MIC. Determining the level of this type of drug is essential to reach the effective concentration that inhibits the growth...