Andrzej Czyrski
Poznan University of Medical Sciences
PharmacokineticsAnalytical chemistryDecompositionOrganic chemistryHigh-performance liquid chromatographyChemistryThin-layer chromatographyPartition coefficientAlkali metalLipophilicityCmaxSalt (chemistry)IsoquinolinePapaverineAcetonitrileAllocryptopineChlorideLevofloxacinTriethylaminePapaveraldinePapaverinolStatistical analysisChromatographyMedicinePharmacology
17Publications
6H-index
104Citations
Publications 17
Newest
#1Agnieszka Karbownik (Poznan University of Medical Sciences)H-Index: 7
#2Danuta Szkutnik-Fiedler (Poznan University of Medical Sciences)H-Index: 6
Last. Edyta Szałek (Poznan University of Medical Sciences)H-Index: 10
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The tyrosine kinase inhibitor sorafenib is the first-line treatment for patients with hepatocellular carcinoma (HCC), in which hyperlipidemia and type 2 diabetes mellitus (T2DM) may often coexist. Protein transporters like organic cation (OCT) and multidrug and toxin extrusion (MATE) are involved in the response to sorafenib, as well as in that to the anti-diabetic drug metformin or atorvastatin, used in hyperlipidemia. Changes in the activity of these transporters may lead to pharmacokinetic in...
3 CitationsSource
#1Aleksandra Czeszak (Adam Mickiewicz University in Poznań)
#2Matylda ResztakH-Index: 5
Last. Izabela Nowak (Adam Mickiewicz University in Poznań)H-Index: 25
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Lipophilicity plays a significant role as a determinant of biological properties. The reversed-phase high-performance thin layer chromatography (HP-TLC) was applied to determine the logP values of chelidonine, allocryptopine, sanguinarine chloride and chelerythrine chloride at three different pH values: 3.0, 7.4 and 10.0. The mobile phase was a mixture of acetonitrile and water with different concentrations of acetonitrile (50-75% vol.). The retention factors, Rm0 values, for the compounds with ...
Source
#1Andrzej Czyrski (Poznan University of Medical Sciences)H-Index: 6
#2Justyna Sznura (Poznan University of Medical Sciences)H-Index: 1
Box-Behnken Design is a useful tool for the optimization of the chromatographic analysis. The goal of this study was to select the most significant factors that influenced the following parameters of the chromatographic separation: retention time, relative retention time, symmetry of the peaks, tailing factor, a number of theoretical plates, Foley – Dorsey parameter, resolution factor, peak width at half height. The results underwent the ANOVA test to find the statistically significant variables...
8 CitationsSource
#1Andrzej Czyrski (Poznan University of Medical Sciences)H-Index: 6
#2Katarzyna Anusiak (Poznan University of Medical Sciences)H-Index: 1
Last. Artur Teżyk (Poznan University of Medical Sciences)H-Index: 9
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In this paper the decomposition product of levofloxacin was identified. Levofloxacin was dissolved in 0.9% NaCl, 5% glucose, and Ringer’s solution. The solutions were divided into two batches: the first one was exposed to daylight and the second one was protected from it. The solutions were stored at the room temperature. The qualitative analysis of the degradation product was performed using MS and TOF detectors. The quantitative assay was done by a validated HPLC method. Visual inspection and ...
5 CitationsSource
#1Andrzej Czyrski (Poznan University of Medical Sciences)H-Index: 6
The lipophilicity is an important parameter that influences the activity of the drugs in the human body. The reversed phase high performance thin layer chromatography was applied to determine the Log P values of ibuprofen, ketoprofen, naproxen, and flurbiprofen. The stationary phase used in the study was silica-gel coated plates. The mobile phase was the mixture of acetonitrile and water in different proportions. The content of acetonitrile varied in 5% increments from 50% to 80%. The Rm0 values...
12 CitationsSource
#1Andrzej Czyrski (Poznan University of Medical Sciences)H-Index: 6
#2Matylda Resztak (Poznan University of Medical Sciences)H-Index: 5
Last. Tadeusz W. Hermann (Poznan University of Medical Sciences)H-Index: 6
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Abstract Type 2 diabetes mellitus is a worldwide health problem. Many drugs can be used in its treatment. One of them is gliclazide – the sulfonylurea derivative. It is dosed in modified release tablets. The study aimed to determine the minimum steady-state concentration of gliclazide at patients taking modified release tablets. Fasting plasma glucose, insulin level, and glycated hemoglobin were also assayed in this study. Ten patients of the primary care physician clinic took 30–90 mg of glicla...
2 CitationsSource
#1Andrzej Czyrski (Poznan University of Medical Sciences)H-Index: 6
ABSTRACT:Fluoroquinolones of the third and fourth generation posses wide bactericidal activity. Monitoring concentrations of antibacterial agents provides effective therapy and prevents the increase of bacterial resistance to antibiotics. The pharmacodynamic parameters that best describe fluoroquinalone activity are AUC/MIC and Cmax/MIC. Determining the level of this type of drug is essential to reach the effective concentration that inhibits the growth of bacteria. Determining the pharmaceutica...
15 CitationsSource
#1Andrzej Czyrski (Poznan University of Medical Sciences)H-Index: 6
#2Agnieszka Sokół (Poznan University of Medical Sciences)H-Index: 1
Last. Edyta Szałek (Poznan University of Medical Sciences)H-Index: 10
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ABSTRACTMoxifloxacin is a representative of the fourth generation of fluoroquinolones. It possesses bacteriostatic activity against Gram-positive and Gram-negative bacteria. A simple and fast high performance liquid chromatography-ultraviolet detection (HPLC-UV) method was developed for moxifloxacin analysis. The separation was performed on C18 column. The mobile phase was a mixture of acetonitrile and 0.4% triethylamine solution. The regression curve was linear over the range 0.2–10.0 µg/mL. Th...
2 CitationsSource
#1Andrzej Czyrski (Poznan University of Medical Sciences)H-Index: 6
#2Edyta Szałek (Poznan University of Medical Sciences)H-Index: 10
Levofloxacin is a bacteriostatic L-isomer of ofloxacin. This drug is a third generation fluoroquinolone. Its activity strongly depends on its concentration and the AUC/MIC ratio is the best indication of drug exposure. A simple, specific and fast HPLC method with fluorescence detection for assay of levofloxacin level in human plasma was developed. The separation was performed on a reversed phase column. The mobile phase contained 0.4% solution of triethylamine. The regression equation was linear...
3 CitationsSource
#1Andrzej Czyrski (Poznan University of Medical Sciences)H-Index: 6
#2Katarzyna Kondys (Poznan University of Medical Sciences)H-Index: 1
Last. Edmund Grześkowiak (Poznan University of Medical Sciences)H-Index: 14
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Abstract Background The aim of this study was to evaluate the impact of sunitinib on pharmacokinetics of levofloxacin. The previous study proved that levofloxacin co-administered with sunitib changes the following pharmacokinetic parameters i.e. Cmax and AUC for both sunitinib and SU012662 (sunitinib metabolite). We will also investigate if the limited sample strategy can be applied for levofloxacin. Methods Rabbits were divided into two groups. In both groups there were six animals. In the cont...
8 CitationsSource