Rules of Engagement: The Type VI Secretion System in Vibrio cholerae

The T6SS is a contact-dependent toxin-delivery machine found in Gram-negative bacteria. Translocation of toxins occurs through a contraction event that propels a membrane-puncturing spike, decorated with effector proteins, into neighboring cells. Vibrio cholerae can use its T6SS against a variety of organisms found in its aquatic and host environments, including neighboring Gram-negative bacteria, phagocytic amoebae, and immune cells. In many V....