Abstract 4022: Fibroblast-derived PEDF inhibits tumor growth and angiogenesis and is suppressed by TGF-β and PDGF

Rationale and Objective: PEDF (pigment epithelium-derived factor) is an endogenous angiogenesis inhibitor and a type II tumor suppressor whose expression is often reduced/ lost in a variety of tumors, including malignant melanoma. To date, the mechanisms and consequences of PEDF loss on tumor progression have been investigated in neoplastic cells but not in the tumor-associated non-neoplastic cells. Fibroblasts are extremely abundant in the...