Nkechiyere G. Nwani
Northwestern University
Drug resistanceTransforming growth factorCancerPhenotypeAutocrine signallingDoppler effectDNA damageFocal adhesionStromal cellTissue transglutaminasePlatelet-derived growth factor receptorChemistryIntegrinIn vitroAldehyde dehydrogenaseTumor microenvironmentGlioblastomaChemotherapyCarcinomaMelanomaSOX2Chemosensitivity assayTumor initiationCell sortingOptical coherence tomographyMetastasisALDH1A1Tumor promotionFibroblastAngiogenesisOvarian cancerNeoplasmStem cellCancer-Associated FibroblastsEpithelial ovarian cancerActin cytoskeletonTumor growthChemo resistanceMembrane rufflingCancer researchPEDFViability assayCancer stem cellBiochemistryMedicineParacrine signallingIntracellularCell cultureAdhesionCell adhesionFibronectinBiologyCell biologyCancer cell
Publications 8
#1Zhe Li (Purdue University)H-Index: 3
#2Ran AnH-Index: 10
Last. David D. Nolte (Purdue University)H-Index: 55
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Development of an assay to predict response to chemotherapy has remained an elusive goal in cancer research. We report a phenotypic chemosensitivity assay for epithelial ovarian cancer based on Doppler spectroscopy of infrared light scattered from intracellular motions in living three-dimensional tumor biopsy tissue measured in vitro. The study analyzed biospecimens from 20 human patients with epithelial ovarian cancer. Matched primary and metastatic tumor tissues were collected for 3 patients, ...
5 CitationsSource
#1Livia Elena Sima (NU: Northwestern University)H-Index: 17
#2Bakhtiyor Yakubov (IU: Indiana University)H-Index: 8
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
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Tissue transglutaminase (TG2) is a multi-functional protein, with enzymatic, GTP-ase and scaffold properties. TG2 interacts with fibronectin (FN) through its N-terminus domain, stabilizing integrin complexes, which regulate cell adhesion to the matrix. Through this mechanism, TG2 participates in key steps involved in metastasis in ovarian and other cancers. High throughput screening identified several small molecule inhibitors (SMIs) for the TG2/FN complex. Rational medicinal chemistry optimizat...
4 CitationsSource
#2Salvatore CondelloH-Index: 18
Last. Daniela MateiH-Index: 59
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#1Nkechiyere G. Nwani (NU: Northwestern University)H-Index: 4
#2Salvatore Condello (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 18
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
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A small of population of slow cycling and chemo-resistant cells referred to as cancer stem cells (CSC) have been implicated in cancer recurrence. There is emerging interest in developing targeted therapeutics to eradicate CSCs. Aldehyde-dehydrogenase (ALDH) activity was shown to be a functional marker of CSCs in ovarian cancer (OC). ALDH activity is increased in cells grown as spheres versus monolayer cultures under differentiating conditions and in OC cells after treatment with platinum. Here, ...
16 CitationsSource
#1Nkechiyere G. Nwani (NU: Northwestern University)H-Index: 4
#2Livia Elena Sima (NU: Northwestern University)H-Index: 17
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
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: Cancer⁻stroma interactions play a key role in cancer progression and response to standard chemotherapy. Here, we provide a summary of the mechanisms by which the major cellular components of the ovarian cancer (OC) tumor microenvironment (TME) including cancer-associated fibroblasts (CAFs), myeloid, immune, endothelial, and mesothelial cells potentiate cancer progression. High-grade serous ovarian cancer (HGSOC) is characterized by a pro-inflammatory and angiogenic signature. This profile is c...
13 CitationsSource
#1Salvatore Condello (NU: Northwestern University)H-Index: 18
#2Nkechiyere G. Nwani (NU: Northwestern University)H-Index: 4
Last. Daniela MateiH-Index: 59
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1 CitationsSource
#1Nkechiyere G. Nwani (NU: Northwestern University)H-Index: 4
#2María Laura Deguiz (CSIC: Spanish National Research Council)H-Index: 3
Last. Olga V. Volpert (NU: Northwestern University)H-Index: 65
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Loss of pigment epithelium-derived factor (PEDF, SERPINF1) in cancer cells is associated with poor prognosis and metastasis, but the contribution of stromal PEDF to cancer evolution is poorly understood. Therefore, we investigated the role of fibroblast-derived PEDF in melanoma progression. We demonstrate that normal dermal fibroblasts expressing high PEDF levels attenuated melanoma growth and angiogenesis in vivo, whereas PEDF-depleted fibroblasts exerted tumor-promoting effects. Accordingly, m...
24 CitationsSource