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Original paper

Effect of Regulatory Element DNA Methylation on Tissue-Type Plasminogen Activator Gene Expression

Volume: 11, Issue: 12, Pages: e0167588 - e0167588
Published: Dec 14, 2016
Abstract
Expression of the tissue-type plasminogen activator gene (t-PA; gene name PLAT) is regulated, in part, by epigenetic mechanisms. We investigated the relationship between PLAT methylation and PLAT expression in five primary human cell types and six transformed cell lines. CpG methylation was analyzed in the proximal PLAT gene promoter and near the multihormone responsive enhancer (MHRE) -7.3 kilobase pairs upstream of the PLAT transcriptional...
Paper Details
Title
Effect of Regulatory Element DNA Methylation on Tissue-Type Plasminogen Activator Gene Expression
Published Date
Dec 14, 2016
Journal
Volume
11
Issue
12
Pages
e0167588 - e0167588
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