The dose–response of salvage radiotherapy following radical prostatectomy: A systematic review and meta-analysis

To date neither the optimal radiotherapy dose nor the existence of a dose-response has been established for salvage RT (SRT).A systematic review from 1996 to 2015 and meta-analysis was performed to identify the pathologic, clinical and treatment factors associated with relapse-free survival (RFS) after SRT (uniformly defined as a PSA>0.2ng/mL or rising above post-SRT nadir). A sigmoidal dose-response curve was objectively fitted and a...