Design and characterization of an APC-specific serpin for the treatment of hemophilia

Blood20.30
Volume: 129, Issue: 1, Pages: 105 - 113
Published: Jan 5, 2017
Abstract
Key Points The endogenous inhibitors of APC also inhibit other coagulation proteases rendering them unacceptable for treatment of hemophilia. Rationally designed APC-specific serpins rescue thrombin generation in vitro and restore hemostasis in hemophilia mouse...
Paper Details
Title
Design and characterization of an APC-specific serpin for the treatment of hemophilia
Published Date
Jan 5, 2017
Journal
Volume
129
Issue
1
Pages
105 - 113
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.