Original paper
Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer
Abstract
Experimental evidence suggest that breast tumors originate from breast cancer stem cells (BCSCs), and that mitochondrial biogenesis is essential for the anchorage-independent clonal expansion and survival of CSCs, thus rendering mitochondria a significant target for novel treatment approaches. One of the recognized side effects of the FDA-approved drug, doxycycline is the inhibition of mitochondrial biogenesis. Here we investigate the mechanism...
Paper Details
Title
Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer
Published Date
Mar 30, 2017
Journal
Volume
16
Issue
8
Pages
737 - 745
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Notes
History