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#1Xiyin Huang (Fujian Medical University)
#2Juanyong Pan (Fujian Medical University)
Last. Xinfeng Li (Fujian Medical University)
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Being one of the most prevalent malignancies, hepatocellular carcinoma (HCC) threatens the health of population all over the world. Numerous researches have confirmed that long noncoding RNAs (lncRNAs) play an important role in tumor progression. Nonetheless, the mechanisms of unc-5 netrin receptor B antisense RNA 1 (UNC5B-AS1) in HCC remain obscure. Thus, this study aims to investigate the regulatory role and mechanism of UNC5B-AS1 in HCC cells. In our research, UNC5B-AS1 was subjected to gene ...
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Abundant researches have stated that long noncoding RNAs (lncRNAs) are crucial molecules in intricate progression of various cancers in terms of their influence on cell stemness. However, no research has discussed the role of LINC00460 in the stemness of hepatocellular carcinoma (HCC). RT-qPCR and western blot were utilized to respectively examine the RNA and protein levels. Aldehyde dehydrogenase 1 (ALDH1) assays and sphere formation assay were performed to detect cell stemness property in vitr...
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Multiple myeloma (MM) remains an incurable hematological malignancy characterized by proliferation and accumulation of plasma cells in the bone marrow. Innovative and effective therapeutic approaches that are able to improve the outcome and the survival of MM sufferers, especially the identification of novel natural compounds and investigation of their anti-MM mechanisms, are needed. Here, we investigated the effects and the potential mechanisms against MM of forskolin, a diterpene derived from ...
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#1Rui Li (Southern Medical University)
#2Xia Qiu (North Sichuan Medical College)
Last. Mei Zhong (Southern Medical University)
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Preeclampsia (PE) is a pregnancy-associated disorder caused by poor placentation. METTL3 as an RNA methyltransferase that plays an essential role in the regulation of the m6A modification. This work investigated the regulation of METTL3-mediated mature miR-497-5p/195-5p cluster in PE progression and identified the downstream mechanisms involved. Differentially expressed miRNAs in PE were obtained from the GSE96983 dataset. The miR-497-5p/195-5p levels in placental samples collected from 20 cases...
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#1Meng Peng (Zhengzhou University)H-Index: 1
#2Yuan Liu (Zhengzhou University)H-Index: 8
Last. Hai-bo Yang (Zhengzhou University)H-Index: 5
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Cathelicidin-WA (CWA) is a novel cathelicidin peptide isolated from snakes that has been suggested to exert anti-inflammatory effects. The aim of our study was to investigate whether cathelicidin-WA (CWA) could protect the heart from diabetic cardiomyopathy (DCM). Streptozotocin (STZ) injection was used to establish a mouse model of DCM. CWA peptide (2 mg/kg or 8 mg/kg) was continuously administered to the mice from 10 weeks to 16 weeks after STZ injection. The mice in the DCM group exhibited ca...
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#1Deling Jiao (Yunnan Agricultural University)H-Index: 3
#2Wenmin Cheng (Yunnan Agricultural University)H-Index: 4
Last. Muhammad Ameen Jamal (Yunnan Agricultural University)H-Index: 4
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Considerable advancements have recently been achieved in porcine somatic cell nuclear transfer (SCNT), but the efficiency remains low. Donor cell size might play an important role in SCNT, but its ...
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#1Yanyan Chen (JLU: Jilin University)
#2Boyang Lu (JLU: Jilin University)
Last. Hui Xu (JLU: Jilin University)
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Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) participate in tumor progression, while the role of PROX1-antisense RNA1 (PROX1-AS1) sponging miR-519d-3p in retinoblastoma (RB) remains largel...
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#1Xingjie Chen (MOE: Chinese Ministry of Education)
#2Yalin Lu (MOE: Chinese Ministry of Education)
Last. Qiang Huang (MOE: Chinese Ministry of Education)H-Index: 1
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MYBL2 has been demonstrated to be an oncogene in some cancers, but there is no pan-cancer analysis at the macro level. We used multiple online or offline bioinformatic tools to examine the effects ...
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#1Chao LvH-Index: 1
#2Jun WangH-Index: 4
Last. Xia LiH-Index: 24
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Objective null Effect of long non-coding RNAs (lncRNAs) on intracranial aneurysm (IA) development has been identified, while the role of noncoding RNA activated by DNA damage (NORAD) in IA remains unexplored. We aimed to verify the impact of NORAD on IA through sponging microRNA-136-5p (miR-136-5p). null Methods null Ruptured and unruptured IAs were harvested from IA patients, and expression of NORAD, miR-136-5p, and KDM1A was determined. The vascular smooth muscle cells (VSMCs) were cultured an...
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#1Jie QuH-Index: 1
#2Xiao-wei XiongH-Index: 1
Last. Liqun Ma
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Alzheimer's disease (AD) is a progressive neuro-degenerative disease characterized by dementia. MicroRNAs (miRNAs) are involved in many diseases, including AD. MiR-132-3p has been identified to be downregulated in AD. In this study, we explored the effects of miR-132-3p on neuron apoptosis and impairments of learning and memory abilities. Aβ1-42-stimulated SH-SY5Y cells were used as in vitro models of AD. An AD-like homocysteine (Hcy) rat model was established to evaluate the effects of miR-132-...
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