LATE-BREAKING ABSTRACT: Lung tumor cell migration and metastasis formation is conversely regulated by transmembrane and cytoplasmic syndecan-1 cleavage fragments

Syndecan-1 is a heparan sulphate proteoglycan expressed on the cell surface and shed by epithelial lung tumors. We here demonstrate that syndecan-1 is critically involved in lung tumor growth and metastasis in vitro and vivo and investigate the regulatory role of its cellular cleavage fragments. Shedding of syndecan-1 from the cell surface generates a transmembrane C-terminal fragment (tCTF), which can be further processed by γ-secretase into a...