Tobias Pasqualon
RWTH Aachen University
EctodomainMacrophage migration inhibitory factorProto-oncogene tyrosine-protein kinase SrcHaematopoiesisMatrix metalloproteinasePaxillinTransmembrane domainDownregulation and upregulationC-C chemokine receptor type 7Chemokine receptorCCR1ChemokineCXCL11Cleavage (embryo)Cell migrationInternalizationPathologyCellFocal adhesionMolecular biologyCell adhesion moleculeProinflammatory cytokineKinaseChemistryIntegrinCyclin D1ImmunologyMicrovesiclesIn vivoTransmembrane proteinInflammationLungDYRK1AMatrigelCytokineADAM10Wound healingAmphiregulinADAM ProteinsTumor Cell MigrationReceptor recyclingCell cycleIn vitro analysisProtein stabilizationLung metastasisLeukocyte migrationKinase activityCX3CR1NeurogenesisCancer researchCell growthSyndecan 1MedicineEnzyme-linked receptorA549 cellCell adhesionFibronectinBiologyC-C chemokine receptor type 6Cell biologyProtein kinase A
10Publications
7H-index
216Citations
Publications 10
Newest
#1Andrea Koenen (RWTH Aachen University)H-Index: 2
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 9
Last. Daniela Dreymueller (RWTH Aachen University)H-Index: 17
view all 9 authors...
The CXC-chemokine receptor 6 (CXCR6) is a class A GTP-binding protein-coupled receptor (GPCRs) that mediates adhesion of leukocytes by interacting with the transmembrane cell surface-expressed chemokine ligand 16 (CXCL16), and also regulates leukocyte migration by interacting with the soluble shed variant of CXCL16. In contrast to virtually all other chemokine receptors with chemotactic activity, CXCR6 carries a DRF motif instead of the typical DRY motif as a key element in receptor activation a...
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#1Esther Groth (RWTH Aachen University)H-Index: 6
#2Jessica Pruessmeyer (RWTH Aachen University)H-Index: 14
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 57
view all 11 authors...
Abstract By mediating proteolytic shedding on the cell surface the disintegrin and metalloproteinases ADAM10 and ADAM17 function as critical regulators of growth factors, cytokines and adhesion molecules. We here report that stimulation of lung epithelial A549 tumor cells with phorbol-12-myristate-13-acetate (PMA) leads to the downregulation of the surface expressed mature form of ADAM17 without affecting ADAM10 expression. This reduction could not be sufficiently explained by metalloproteinase-...
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#1Tobias Pasqualon (RWTH Aachen University)H-Index: 7
#2Hongqi Lue (RWTH Aachen University)H-Index: 24
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 57
view all 8 authors...
Surface expressed proteoglycans mediate the binding of cytokines and chemokines to the cell surface and promote migration of various tumor cell types including epithelial tumor cells. We here demonstrate that binding of the chemokine-like inflammatory cytokine macrophage migration inhibitory factor (MIF) to epithelial lung and breast tumor cell lines A549 and MDA-MB231 is sensitive to enzymatic digestion of heparan sulphate chains and competitive inhibition with heparin. Moreover, MIF interactio...
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#1Tobias PasqualonH-Index: 7
#2Andreas LudwigH-Index: 43
view all 3 authors...
#1Tobias Pasqualon (RWTH Aachen University)H-Index: 7
#2Jessica Pruessmeyer (RWTH Aachen University)H-Index: 14
Last. Andreas LudwigH-Index: 57
view all 14 authors...
// Tobias Pasqualon 1 , Jessica Pruessmeyer 1 , Vera Jankowski 2 , Aaron Babendreyer 1 , Esther Groth 1 , Julian Schumacher 1 , Andrea Koenen 1 , Sarah Weidenfeld 1 , Nicole Schwarz 3 , Bernd Denecke 4 , Holger Jahr 5 , Daniela Dreymueller 1 , Joachim Jankowski 2 , Andreas Ludwig 1 1 Institute of Pharmacology and Toxicology, RWTH Aachen University, Aachen, Germany 2 Institute of Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany 3 Institute of Molecular and Cellular Anato...
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#1Tobias Pasqualon (RWTH Aachen University)H-Index: 7
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 9
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 43
view all 6 authors...
Syndecan-1 is a heparan sulphate proteoglycan expressed on the cell surface and shed by epithelial lung tumors. We here demonstrate that syndecan-1 is critically involved in lung tumor growth and metastasis in vitro and vivo and investigate the regulatory role of its cellular cleavage fragments. Shedding of syndecan-1 from the cell surface generates a transmembrane C-terminal fragment (tCTF), which can be further processed by γ-secretase into a cytoplasmic fragment (cCTF). Scratch-induced wound ...
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#1Tobias Pasqualon (RWTH Aachen University)H-Index: 7
#2Jessica Pruessmeyer (RWTH Aachen University)H-Index: 14
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 57
view all 12 authors...
Syndecan-1 is a heparan sulfate proteoglycan expressed by endothelial and epithelial cells and involved in wound healing and tumor growth. Surface-expressed syndecan-1 undergoes proteolytic shedding leading to the release of the soluble N-terminal ectodomain from a transmembrane C-terminal fragment (tCTF). We show that the disintegrin and metalloproteinase (ADAM) 17 generates a syndecan-1 tCTF, which can then undergo further intra-membrane proteolysis by γ-secretase. Scratch-induced wound closur...
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#1Jessica PruessmeyerH-Index: 14
#2Franz M. HessH-Index: 6
Last. Andreas LudwigH-Index: 57
view all 15 authors...
Inflammation is a key process in various diseases, characterized by leukocyte recruitment to the inflammatory site. This study investigates the role of a disintegrin and a metalloproteinase (ADAM) 10 and ADAM17 for leukocyte migration in vitro and in a murine model of acute pulmonary inflammation.
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#1Ulf Soppa (Universidad Miguel Hernández de Elche)H-Index: 1
#2Julian Schumacher (RWTH Aachen University)H-Index: 8
Last. Walter Becker (RWTH Aachen University)H-Index: 39
view all 6 authors...
A fundamental question in neurobiology is how the balance between proliferation and differentiation of neuronal precursors is maintained to ensure that the proper number of brain neurons is generated. Substantial evidence implicates DYRK1A (dual specificity tyrosine-phosphorylation-regulated kinase 1A) as a candidate gene responsible for altered neuronal development and brain abnormalities in Down syndrome. Recent findings support the hypothesis that DYRK1A is involved in cell cycle control. Non...
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