Aaron Babendreyer
RWTH Aachen University
Endothelial stem cellDownregulation and upregulationChemokineCell migrationPathologyCellMolecular biologyCell adhesion moleculeTumor necrosis factor alphaChemistryInflammationLungADAM8Cancer researchCell growthSyndecan 1MedicineA549 cellBiologyCell biology
20Publications
8H-index
184Citations
Publications 20
Newest
#1Chen Zhou (RWTH Aachen University)H-Index: 2
#2Sebastian Bette (RWTH Aachen University)H-Index: 3
Last. Uwe Schnakenberg (RWTH Aachen University)H-Index: 33
view all 11 authors...
Abstract Stretchable microelectrodes paired with an ultra-elastic substrate can be used for electrical sensing of mechanically stretched cells and cell monolayers. Here, we present the development of a cell-stretching platform with thin-film interdigitated microelectrodes. Up to 35% cyclic stretch are feasible with a novel interlaced meander design connected to the microelectrodes and using Poly(dimethylsiloxane) (PDMS) with a Young’s modulus of 50 kPa as an ultra-elastic substrate. Reliable ele...
Source
#2Sergej KlassenH-Index: 1
Last. Christian MartinH-Index: 20
view all 7 authors...
Retrograde perfusion may occur during disease, surgery or extracorporeal circulation. While it is clear that endothelial cells sense and respond to changes in blood flow, the consequences of retrograde perfusion are only poorly defined. Similar to shear stress or disturbed flow, retrograde perfusion might result in vasomotor responses, edema formation or inflammation in and around vessels. In this study we investigated in rats the effects of retrograde perfusion in isolated systemic vessels (IPV...
Source
#1Tanzeela Awan (RWTH Aachen University)H-Index: 1
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 10 authors...
Acute and chronic liver inflammation is driven by cytokine and chemokine release from various cell types in the liver. Here, we report that the induction of inflammatory mediators is associated with a yet undescribed upregulation of the metalloproteinase ADAM8 in different murine hepatitis models. We further show the importance of ADAM8 expression for the production of inflammatory mediators in cultured liver cells. As a model of acute inflammation, we investigated liver tissue from lipopolysacc...
Source
#1Tanzeela Awan (RWTH Aachen University)H-Index: 1
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 8 authors...
Hepatocellular carcinoma (HCC) is one of the most common metastatic tumours. Tumour growth and metastasis depend on the induction of cell proliferation and migration by various mediators. Here, we report that the A Disintegrin and Metalloproteinase (ADAM) 8 is highly expressed in murine HCC tissues as well as in murine and human hepatoma cell lines Hepa1-6 and HepG2, respectively. To establish a dose-dependent role of different ADAM8 expression levels for HCC progression, ADAM8 expression was ei...
1 CitationsSource
#1Aaron Babendreyer (RWTH Aachen University)H-Index: 8
#2Andreas Ludwig (RWTH Aachen University)H-Index: 63
Source
#1Aaron BabendreyerH-Index: 8
#2Diana M. Rojas-González (TUM: Technische Universität München)H-Index: 1
Last. Andreas LudwigH-Index: 35
view all 7 authors...
Background: Endothelial function significantly depends on the proteolytic release of surface expressed signal molecules, their receptors and adhesion molecules via the metalloproteinase ADAM17. The pseudoproteases iRhom1 and 2 independently function as adapter proteins for ADAM17 and are essential for the maturation, trafficking, and activity regulation of ADAM17. Bioinformatic data confirmed that immune cells predominantly express iRhom2 while endothelial cells preferentially express iRhom1. Ob...
1 CitationsSource
#1Aaron Babendreyer (RWTH Aachen University)H-Index: 8
#2Lisa Molls (RWTH Aachen University)H-Index: 2
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 63
view all 11 authors...
Abstract Reduced shear stress resulting from disturbed blood flow can impair endothelial integrity and drive the development of vascular inflammatory lesions. Metalloproteinases of the ADAM family have been implicated in the regulation of cell survival and inflammatory responses. Here we investigate the mechanism and function of ADAM15 upregulation in primary flow cultured endothelial cells. Transcriptomic analysis indicated that within the ADAM family ADAM15 mRNA is most prominently upregulated...
10 CitationsSource
#1Stefan Düsterhöft (RWTH Aachen University)H-Index: 11
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Andreas Ludwig (RWTH Aachen University)H-Index: 35
view all 5 authors...
Abstract Several membrane-bound proteins with a single transmembrane domain are subjected to limited proteolysis at the cell surface. This cleavage leads to the release of their biologically active ectodomains, which can trigger different signalling pathways. In many cases, this ectodomain shedding is mediated by members of the family of a disintegrins and metalloproteinases (ADAMs). ADAM17 in particular is responsible for the cleavage of several proinflammatory mediators, growth factors, recept...
20 CitationsSource
#1Daniel Schick (RWTH Aachen University)H-Index: 2
#2Aaron Babendreyer (RWTH Aachen University)H-Index: 8
Last. Daniela Dreymueller (Saarland University)H-Index: 16
view all 13 authors...
Abstract Background and aims Members of the family of a disintegrin and metalloproteinases (ADAMs) and their substrates have been previously shown to modulate the inflammatory response in cardiac diseases, but studies investigating the relevance of ADAM8 are still rare. Our aim is to provide evidence for the inflammatory dysregulation of ADAM8 in vascular diseases and its association with disease severity. Methods Western-type diet fed Apoe−/− and Ldlr−/− mice and artery ligation served as murin...
6 CitationsSource
#1Said Suleiman (RWTH Aachen University)H-Index: 4
#2Sergej Klassen (RWTH Aachen University)H-Index: 1
Last. Annette D. Rieg (RWTH Aachen University)H-Index: 11
view all 17 authors...
Argon exerts neuroprotection. Thus, it might improve patients’ neurological outcome after cerebral disorders or cardiopulmonary resuscitation. However, limited data are available concerning its effect on pulmonary vessel and airways. We used rat isolated perfused lungs (IPL) and precision-cut lung slices (PCLS) of rats and humans to assess this topic. IPL: Airway and perfusion parameters, oedema formation and the pulmonary capillary pressure (Pcap) were measured and the precapillary and postcapi...
4 CitationsSource