Selective Vulnerability of Cerebral Cortex Regions to Radiation Dose–Dependent Atrophy

Brain radiation therapy (RT) is associated with cognitive impairment, which may be mediated in part by damage to cerebral cortex. Neurological deficits observed after RT typically involve decreased higher cognitive functions (i.e., attention and memory) rather than somatosensory defects or paralysis. We sought to find out whether higher-order association cortex is selectively vulnerable to radiation-induced atrophy using quantitative volumetric...