The impact of margin status determined by the one-millimeter rule on tumor recurrence and survival following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma

Published on Apr 1, 2017in Surgery Today1.878
· DOI :10.1007/S00595-016-1420-7
Takeo Nitta6
Estimated H-index: 6
(Hokkaido University),
Toru Nakamura16
Estimated H-index: 16
(Hokkaido University)
+ 11 AuthorsSatoshi Hirano57
Estimated H-index: 57
(Hokkaido University)
Sources
Abstract
Purpose The tumor-node-metastasis (TNM) classification defines R1 as the presence of tumor cells at the resection margin, while the current Royal College of Pathologists guidelines for pancreaticoduodenectomy specimens regard the presence of tumor cells within 1 mm from the resection margin as R1 (the “1-mm rule”). The aims of this study were to investigate the resection margin status of pancreatic head cancer retrospectively according to both the TNM and 1-mm rule classifications, and to evaluate the postoperative survival and tumor recurrence patterns.
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