Multi b-value Diffusion Imaging of Radiation-Induced White Matter Damage

Radiotherapy for brain tumors is limited in part by collateral damage to white matter and its extra-axonal matrix, likely contributing to post-radiation neurocognitive decline. We utilized diffusion tensor imaging (DTI) with multiple b-values (diffusion weightings) to model the effects of radiation on intra-axonal and extra-axonal white matter. Fifteen patients with high-grade glioma treated with radiotherapy and chemotherapy underwent MRI with...