Original paper
ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis
Abstract
ADAMTS13 cleaves ultralarge multimeric von Willebrand Factor (VWF), thereby preventing formation of platelet-rich microthrombi. ADAMTS13 is mainly produced by hepatic stellate cells, and numerous studies have suggested a functional role of ADAMTS13 in the pathogenesis of liver diseases. The aim of our study was to investigate a potential role of ADAMTS13 in formation of hepatic microthrombi and development of non-alcoholic steatohepatitis...
Paper Details
Title
ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis
Published Date
Jan 1, 2017
Journal
Volume
117
Issue
01
Pages
19 - 26
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Notes
History