Thrombosis and Haemostasis
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#1Fahd A. Kuriri (Shaqra University)H-Index: 2
#2Genia F. Burchall (RMIT: RMIT University)H-Index: 4
Last. Denise E. Jackson (RMIT: RMIT University)H-Index: 23
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The immunoglobulin (Ig)–immunoreceptor tyrosine–based inhibitory motif (ITIM) bearing receptors, PECAM-1 and CEACAM1 have been shown net negative regulators of platelet-collagen interactions and hemi-ITAM signalling pathways. null In this study, a double knockout (DKO) mouse null was developed with deleted PECAM-1 and CEACAM1 to study their combined contribution in platelet activation by glycoprotein VI, C-type lectin-like receptor 2 (CLEC-2), protease activated receptor PAR-4, ADP purinergic re...
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#1Amy K Searle (The Heart Research Institute)
#2Yung-Chih Chen (The Heart Research Institute)H-Index: 19
Last. Hadi Lioe (CSL Limited)H-Index: 1
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Background null 3F7 is a monoclonal antibody targeting the enzymatic pocket of FXIIa, thereby inhibiting its catalytic activity. Given the emerging role of FXIIa in promoting thrombo-inflammation, along with its apparent redundancy for haemostasis, the selective inhibition of FXIIa represents a novel and highly attractive approach targeting pathogenic processes that cause thromboinflammation-driven cardiovascular diseases. null Methods null The effects of FXIIa inhibition were investigated using...
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#1Emily Janus-Bell (UDS: University of Strasbourg)H-Index: 2
#2Alexandra A. Yakusheva (UDS: University of Strasbourg)H-Index: 1
Last. Yotis A. Senis (UDS: University of Strasbourg)H-Index: 1
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Objective: Integrins are key regulators of various platelet functions. The pathophysiological importance of most platelet integrins has been investigated, with the exception of α5β1, a receptor for fibronectin. The aim of this study was to characterize the role of α5β1 in megakaryopoiesis, platelet function, and to determine its importance in hemostasis and arterial thrombosis. Approach and results: We generated a mouse strain deficient for integrin α5β1 on megakaryocytes and platelets (PF4Cre-α...
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#1Job Harenberg (Heidelberg University)H-Index: 36
#2Marina MarchettiH-Index: 27
Last. Anna FalangaH-Index: 76
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Vaccination against the SARS-CoV-2 may lead to immunologic reactions activating the haemostatic system and resulting in both venous and arterial thromboembolism. Aquired autoimmune Haemophilia following SARS-CoV-2 vaccines were now reported 15 to 19 days (or later) after vaccination and resolution of symptoms by adequate treatment of the immunologic reaction. From patients' point of view, anticoagulants and SARS-CoV-2 vaccines share their capacity to induce thrombosis as well as bleeding and cli...
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#1Marc Hoylaerts (Katholieke Universiteit Leuven)H-Index: 79
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#1Yun Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Jian-Hua Mao (SJTU: Shanghai Jiao Tong University)H-Index: 55
Last. Chao Fang (HUST: Huazhong University of Science and Technology)
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Platelet-targeted FVIII gene therapy can efficiently recover bleeding phenotype for hemophilia A (HA), yet characteristics of thrombus formation with this ectopic expression of factor VIII (FVIII) in platelets remain unclear. Here, we generated 2bF8trans mice restrictively expressing human B-domain–deleted FVIII (hBDD FVIII) in platelets on a hemophilic (FVIIInull) mice background. The results showed no statistical difference in clot strength and stability between wild-type (WT) and 2bF8trans mi...
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#1Katharina Holstein (UHH: University of Hamburg)H-Index: 11
#2Leonora Witt (UHH: University of Hamburg)H-Index: 1
Last. Florian Langer (UHH: University of Hamburg)H-Index: 5
view all 8 authors...
Low bone mineral density (BMD) is common in patients with hemophilia (PWHs). The aim of the present study was to describe BMD and microarchitecture in PWHs in Northern Germany and to determine factors contributing to possible skeletal alterations. Demographic characteristics, BMD and microarchitecture, bone metabolism markers, and orthopaedic joint score (OJS) were assessed during routine check-ups. Areal BMD was assessed by dual-energy X-ray absorptiometry (DXA) at the hip and lumbar spine. Vol...
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#1Olivier SanchezH-Index: 26
#2Anais Charles-Nelson (French Institute of Health and Medical Research)H-Index: 1
Last. Philippe GirardH-Index: 32
view all 28 authors...
Intermediate-high-risk pulmonary embolism (PE) is characterized by right ventricular (RV) dysfunction and elevated circulating cardiac troponin levels despite apparent hemodynamic stability at presentation. In these patients, full-dose systemic thrombolysis reduced the risk of hemodynamic decompensation or death but increased the risk of life-threatening bleeding. Reduced-dose thrombolysis may be capable of improving safety while maintaining reperfusion efficacy. The Pulmonary Embolism Internati...
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#2Gabriel Chodick (TAU: Tel Aviv University)H-Index: 42
Last. Jessica J. Jalbert (Regeneron)H-Index: 2
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The objective of this study was to assess the relationship between factor XI (FXI) deficiency and the risks of bleeding and cardiovascular (CV) events. We conducted a retrospective cohort study using data from Maccabi Healthcare Services (MHS). We identified adults with FXI deficiency (severe:
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#1Maria A. de Winter (UU: Utrecht University)H-Index: 1
#2Jannick A.N. Dorresteijn (UU: Utrecht University)H-Index: 18
Last. Pedro Ruiz Artacho (University of Navarra)
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Background Bleeding risk is highly relevant for treatment decisions in cancer-associated thrombosis (CAT). Several risk scores exist, but have never been validated in patients with CAT and are not recommended for practice. null null null null Objectives To compare methods of estimating clinically relevant (major and clinically relevant nonmajor) bleeding risk in patients with CAT: (1) existing risk scores for bleeding in venous thromboembolism, (2) pragmatic classification based on cancer type, ...
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