Original paper
Loss of Mbd2 Protects Mice Against High-Fat Diet–Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure
Abstract
Previous studies including ours demonstrated that methyl-CpG-binding domain 2 (MBD2) acts as a reader to decipher DNA methylome-encoded information. We thus in the current study used Mbd2-/- mice as a model to dissect the impact of high-fat diet (HFD) on DNA methylome relevant to the pathoetiology of obesity. It was interestingly noted that mice deficient in Mbd2 were protected from HFD-induced obesity and insulin resistance. Mechanistic study...
Paper Details
Title
Loss of Mbd2 Protects Mice Against High-Fat Diet–Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure
Published Date
Aug 23, 2016
Journal
Volume
65
Issue
11
Pages
3384 - 3395