Diabetes
IF
9.46
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Newest
#1Morgan J Smith (UF: University of Florida)
#2Lucia Pastor (UF: University of Florida)
Last. Patrick Concannon (UF: University of Florida)H-Index: 77
view all 4 authors...
Signal regulatory protein SIRPγ (CD172G) is expressed on the surface of lymphocytes where it acts by engaging its ligand, CD47. SIRPG, which encodes SIRPγ, contains a non-synonymous coding variant, rs6043409, which is significantly associated with risk for type 1 diabetes. SIRPG produces multiple transcript isoforms via alternative splicing, all encoding potentially functional proteins. We show that rs6043409 alters a predicted exonic splicing enhancer, resulting in significant shifts in the dis...
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#1Marion Ouidir (NIH: National Institutes of Health)H-Index: 8
#2Xuehuo Zeng (NIH: National Institutes of Health)H-Index: 3
Last. Fasil Tekola-Ayele (NIH: National Institutes of Health)H-Index: 19
view all 5 authors...
Maternal genetic variants associated with offspring birth weight and adult type 2 diabetes (T2D) risk loci show some overlap. Whether T2D genetic risk influences longitudinal fetal weight and the gestational timing when these relationships begin is unknown. We investigated the associations of T2D genetic risk score (GRS) with longitudinal fetal weight and birth weight among 1,513 pregnant women from four ancestral groups. Women had up to 5 ultrasonography. Ancestry-matched GRS were constructed s...
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#1Kevin ColcloughH-Index: 21
#2Sian Ellard (University of Exeter)H-Index: 109
Last. Kashyap A. Patel (University of Exeter)H-Index: 17
view all 4 authors...
At present, outside of infancy, genetic testing for monogenic diabetes is typically for mutations in MODY genes that predominantly result in isolated diabetes. Monogenic diabetes syndromes are usually only tested when this is supported by specific syndromic clinical features. It is not known how frequently patients with suspected MODY have a mutation in a monogenic syndromic diabetes gene and thus missed by present testing regimes. null We performed genetic testing of 27 monogenic diabetes genes...
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#1Shafqat Ahmad (BWH: Brigham and Women's Hospital)H-Index: 23
#2Ulf Hammar (Science for Life Laboratory)H-Index: 2
Last. Tove Fall (Science for Life Laboratory)H-Index: 47
view all 13 authors...
Obesity is associated with adverse health outcomes, but the metabolic effects have not yet been fully elucidated. We aimed to investigate the association between adiposity with circulating metabolites and to address causality with Mendelian randomization (MR). Metabolomics data was generated by non-targeted ultra-performance liquid-chromatography coupled to time-of-flight mass-spectrometry in plasma and serum from three population-based Swedish cohorts: ULSAM (N=1,135), PIVUS (N=970), and TwinGe...
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#1William T. Cefalu (NIH: National Institutes of Health)H-Index: 4
#2Dana K. Andersen (NIH: National Institutes of Health)H-Index: 23
Last. Norman D. Rosenblum (University of Toronto)H-Index: 12
view all 8 authors...
One hundred years have passed since the discovery of insulin—an achievement that transformed diabetes from a fatal illness into a manageable chronic condition. The decades since that momentous achievement have brought ever more rapid innovation and advancement in diabetes research and clinical care. To celebrate the important work of the past century and help to chart a course for its continuation into the next, the Canadian Institutes of Health Research9s Institute of Nutrition, Metabolism and ...
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#1Yao Xie (ZJU: Zhejiang University)H-Index: 5
#2Yongli Ji (ZJU: Zhejiang University)H-Index: 3
Last. Meixiang Xiang (ZJU: Zhejiang University)H-Index: 29
view all 11 authors...
Adipose derived stem cells (ADSCs) can differentiate into vascular lineages and participate in vascular remodeling. Perivascular ADSCs (PV-ADSCs) draw attention due to their unique location. The heterogeneity of subcutaneous (SUB-) and abdominal ADSCs were well addressed, but PV-ADSCs' heterogeneity hasn't been investigated. In the present study, we applied single-cell analysis to compare SUB-ADSCs and PV-ADSCs respectively regarding their subpopulations, functions, and cell fates. We uncovered ...
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#1Jones K. Ofori (Lund University)H-Index: 10
#2Alexandros Karagiannopoulos (Lund University)H-Index: 1
Last. Lena Eliasson (Lund University)H-Index: 61
view all 8 authors...
MicroRNAs (miRNAs) are part of deregulated insulin secretion in type 2 diabetes (T2D) development. Rodent models have suggested miR-200c to be involved, but the role and potential as therapeutic target of this miRNA in human islets is not clear. Here we report increased expression of miR-200c in islets from T2D as compared with non-diabetic (ND) donors and display results showing reduced glucose-stimulated insulin secretion in EndoC-βH1 cells overexpressing miR-200c. We identify transcription fa...
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#1Fernando Riveros-Mckay (WTSI: Wellcome Sanger Institute)H-Index: 6
#2David J. Roberts (NIHR: National Institute for Health Research)H-Index: 59
Last. Inês Barroso (WTSI: Wellcome Sanger Institute)H-Index: 110
view all 9 authors...
Fructosamine is a measure of short-term glycemic control, which has been suggested as a useful complement to glycated hemoglobin (HbA1c) for the diagnosis and monitoring of diabetes. To date, a single genome-wide association study (GWAS) including 8,951 US White and 2,712 US Black individuals without a diabetes diagnosis has been published. Results in Whites and Blacks yielded different association loci, near RCN3 and CNTN5, respectively. Here we performed a GWAS on 20,734 European ancestry bloo...
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#1Amy Zheng (UM: University of Michigan–Ann Arbor)
#2Edward B. Arias (UM: University of Michigan–Ann Arbor)H-Index: 21
Last. Gregory D. Cartee (UM: University of Michigan–Ann Arbor)H-Index: 49
view all 7 authors...
One exercise session can elevate insulin-stimulated glucose uptake (ISGU) in skeletal muscle, but the mechanisms remain elusive. Circumstantial evidence suggests a role for Akt substrate of 160 kDa (AS160 or TBC1D4). We used genetic approaches to rigorously test this idea. The initial experiment evaluated AS1609s role for the postexercise increase in ISGU using muscles from male wildtype (WT) and AS160-knockout (AS160-KO) rats. The next experiment used AS160-KO rats with an adeno-associated viru...
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#1Zhichao Zhou (KI: Karolinska Institute)H-Index: 23
#2A Collado (KI: Karolinska Institute)
Last. John Pernow (KI: Karolinska Institute)H-Index: 70
view all 18 authors...
Red blood cells (RBCs) act as mediators of vascular injury in type 2 diabetes mellitus (T2DM). miR-210 plays a protective role in cardiovascular homeostasis and is decreased in whole blood of T2DM mice. We hypothesized that downregulation of RBC miR-210 induces endothelial dysfunction in T2DM. RBCs were co-incubated with arteries and endothelial cells ex vivo and transfused in vivo to identify the role of miR-210 and its target protein tyrosine phosphatase 1B (PTP1B) in endothelial dysfunction. ...
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