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#1Nicholas Bowker (University of Cambridge)H-Index: 4
#2Robert Hansford (University of Cambridge)
Last. Fiona M. Gribble (University of Cambridge)H-Index: 91
view all 15 authors...
There is considerable interest in GIPR agonism to enhance the insulinotropic and extra-pancreatic effects of GIP, thereby improving glycaemic and weight control in type 2 diabetes (T2D) and obesity. Recent genetic epidemiological evidence has implicated higher GIPR-mediated GIP levels in raising coronary artery disease (CAD) risk, a potential safety concern for GIPR agonism. We therefore aimed to quantitatively assess whether the association between higher GIPR-mediated fasting GIP levels and CA...
#1Maria Booth Nielsen (Copenhagen University Hospital)H-Index: 1
#2Yunus ÇolakH-Index: 15
Last. Børge G. Nordestgaard (Copenhagen University Hospital)H-Index: 158
view all 4 authors...
We tested the hypothesis that low plasma adiponectin is observationally and genetic, causally associated with increased risk of type 2 diabetes. Observational analyses are prone to confounding and reverse causation, while genetic Mendelian randomization analyses are much less influenced by these biases. We examined 30,045 Copenhagen individuals observationally (1,751 type 2 diabetes; plasma adiponectin), 96,903 Copenhagen individuals using one-sample Mendelian randomization (5,012 type 2 diabete...
#1Min Zhao (University of Paris)H-Index: 15
#2Emmanuelle Gelize (University of Paris)H-Index: 3
Last. Eric Pussard (Université Paris-Saclay)
view all 14 authors...
Diabetic retinopathy remains a major cause of vision loss worldwide. Mineralocorticoid receptor (MR) pathway activation contributes to diabetic nephropathy but its role in retinopathy is unknown. In this study, we show that MR is overexpressed in the retina of type 2 diabetic Goto-Kakizaki (GK) rats and humans and, that cortisol is the MR ligand in human eyes. Lipocalin 2 and galectin 3, two biomarkers of diabetic complications regulated by MR are increased in GK and human retina. The sustained ...
#1Alexander Becker (Saarland University)H-Index: 2
#2Barbara Wardas (Saarland University)H-Index: 1
Last. Veit Flockerzi (Saarland University)H-Index: 79
view all 11 authors...
Voltage-gated Ca2+ (Cav) channels consist of a pore-forming Cavα1 subunit and auxiliary Cavα2-δ and Cavβ subunits. In fibroblasts, Cavβ3, independent of its role as a Cav subunit, reduces the sensitivity to low concentrations of inositol-1,4,5-trisphosphate (IP3). Similarly, Cavβ3 could affect cytosolic [Ca2+] in pancreatic β-cells. Here, we deleted the Cavβ3-encoding gene Cacnb3 in insulin-secreting rat β-(Ins-1) cells using CRISPR/Cas9. These cells were used as controls to investigate the role...
#1Decio L. Eizirik (ULB: Université libre de Bruxelles)H-Index: 103
#2Florian Szymczak (ULB: Université libre de Bruxelles)H-Index: 2
Last. Frank Martin (JDRF)H-Index: 1
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Completion of the Human Genome Project enabled a novel systems- and network-level understanding of biology, but this remains to be applied for understanding the pathogenesis of type 1 diabetes (T1D). We propose that defining the key gene regulatory networks that drive β-cell dysfunction and death in T1D might enable the design of therapies that target the core disease mechanism, namely, the progressive loss of pancreatic β-cells. Indeed, many successful drugs do not directly target individual di...
#1Kierstin L Webster (U of C: University of Chicago)
#2Lev Becker (U of C: University of Chicago)H-Index: 17
#1Thomas Kjeldsen (Novo Nordisk)H-Index: 26
#2Peter Kurtzhals (Novo Nordisk)H-Index: 15
#1Philippe P. Pagni (Novo Nordisk)H-Index: 4
#2Chaplin Jay (Novo Nordisk)
Last. Shangjin Li (Novo Nordisk)
view all 16 authors...
Type 1 diabetes is an autoimmune disease in which insulin-secreting β-cells are destroyed, leading to a life-long dependency on exogenous insulin. There are no approved disease-modifying therapies available, and future immunotherapies would need to avoid generalized immune suppression. We developed a novel plasmid expressing preproinsulin2 and a combination of immune-modulatory cytokines (transforming growth factor-beta-1, interleukin [IL] 10 and IL-2) capable of near-complete prevention of auto...
#1Tito Borner (UPenn: University of Pennsylvania)H-Index: 10
#2Caroline E. Geisler (UPenn: University of Pennsylvania)H-Index: 1
Last. Jane Gaisinsky (UPenn: University of Pennsylvania)
view all 20 authors...
Glucagon-like peptide-1 receptor (GLP-1R) agonists decrease body weight and improve glycemic control in obesity and diabetes. Patient compliance and maximal efficacy of GLP-1 therapeutics are limited by side effects including nausea and emesis. In three different species (i.e., mice, rats, and musk shrews), we show that glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling blocks emesis and attenuates illness behaviors elicited by GLP-1R activation, while maintaining reduced foo...
#1Huanqing Gao (Southern University of Science and Technology)H-Index: 6
#2Yiming Zhong (Southern University of Science and Technology)
Last. Fan Yang (CAS: Chinese Academy of Sciences)
view all 14 authors...
The mammalian focal adhesion proteins Pinch1/2 activate integrins and promote cell-ECM adhesion and migration; however, their roles in adipose tissue and metabolism are unclear. Here we find that high fat diet (HFD) feeding dramatically increases expression of Pinch1 protein in white adipose tissues (WAT) in mice. Furthermore, expression of Pinch1 is largely up-regulated in WAT in the Leptin-deficient ob/ob type 2 diabetic mice and obese humans. While mice with the loss of Pinch1 in adipocytes o...
Top fields of study
Type 2 diabetes
Insulin resistance
Diabetes mellitus