Original paper
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling
Abstract
Coupling distances between synaptic vesicles and Ca2+ channels determine the efficacy of neurotransmission. Böhme et al. find that presynaptic scaffold complexes spatiotemporally control Unc13 isoforms to establish two independent release pathways at subsynaptic active zones: Unc13B defines nascent, loosely coupled synapses whereas Unc13A facilitates release at mature synapses by tight coupling between Ca2+ channels and synaptic vesicles. Brain...
Paper Details
Title
Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca2+ channel–vesicle coupling
Published Date
Aug 15, 2016
Journal
Volume
19
Issue
10
Pages
1311 - 1320