Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex

Cell64.50
Volume: 166, Issue: 5, Pages: 1147 - 1162.e15
Published: Aug 1, 2016
Abstract
Alternative splicing is prevalent in the mammalian brain. To interrogate the functional role of alternative splicing in neural development, we analyzed purified neural progenitor cells (NPCs) and neurons from developing cerebral cortices, revealing hundreds of differentially spliced exons that preferentially alter key protein domains-especially in cytoskeletal proteins-and can harbor disease-causing mutations. We show that Ptbp1 and Rbfox...
Paper Details
Title
Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex
Published Date
Aug 1, 2016
Journal
Volume
166
Issue
5
Pages
1147 - 1162.e15
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