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#1Nikki Traylor-Knowles (UM: University of Miami)H-Index: 15
Coral reefs are one of the most important ecosystems in the world but least understood from a cellular level. In this issue of Cell, Levy et al. unravel the single-cell gene expression of the coral holobiont and open the doors to better understand the novel diversity of cell types.
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The COVID-19 pandemic has highlighted structural inequalities and racism promoting health disparities among communities of color. Taking cardiovascular disease as an example, we provide a framework for multidisciplinary efforts leveraging translational and epidemiologic approaches to decode the biological impacts of inequalities and racism and develop targeted interventions that promote health equity.
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#1Philippa T. K. Saunders (Edin.: University of Edinburgh)H-Index: 88
#2Andrew W Horne (Edin.: University of Edinburgh)H-Index: 37
Summary Endometriosis is a common condition associated with infertility that causes chronic pain in many, but not all, women. It is defined by the presence of endometrial-like tissue outside the uterus. Although the cause and natural history of the disorder remain uncertain, hormonal, neurological, and immunological factors are all implicated in the mechanisms contributing to development of symptoms. Because definitive diagnosis requires surgery, there is often a long diagnostic delay after onse...
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#1Yuhan Hao (NYU: New York University)H-Index: 8
#2Stephanie Hao (Harvard University)H-Index: 4
Last. Rahul Satija (NYU: New York University)H-Index: 50
view all 25 authors...
The simultaneous measurement of multiple modalities represents an exciting frontier for single-cell genomics and necessitates computational methods that can define cellular states based on multimodal data. Here, we introduce "weighted-nearest neighbor" analysis, an unsupervised framework to learn the relative utility of each data type in each cell, enabling an integrative analysis of multiple modalities. We apply our procedure to a CITE-seq dataset of 211,000 human peripheral blood mononuclear c...
7 CitationsSource
#1Ao Liu (HHMI: Howard Hughes Medical Institute)
#2Dominique C. Bergmann (HHMI: Howard Hughes Medical Institute)H-Index: 40
The functional regulatory elements of agronomically important plant genomes have been long sought after. Marand et. al. generate a comprehensive atlas of cis-regulatory elements at single cell resolution in maize, providing a powerful resource for inquiries into the rules of multicellular development and for precision crop engineering.
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#1Haifeng Jiao (Centre for Life)
#2Dong Jiang (Centre for Life)
Last. Li Yu (Centre for Life)H-Index: 75
view all 13 authors...
Damaged mitochondria need to be cleared to maintain the quality of the mitochondrial pool. Here, we report mitocytosis, a migrasome-mediated mitochondrial quality-control process. We found that, upon exposure to mild mitochondrial stresses, damaged mitochondria are transported into migrasomes and subsequently disposed of from migrating cells. Mechanistically, mitocytosis requires positioning of damaged mitochondria at the cell periphery, which occurs because damaged mitochondria avoid binding to...
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#1Jonathan J. Wilde (MIT: Massachusetts Institute of Technology)H-Index: 11
#2Tomomi Aida (MIT: Massachusetts Institute of Technology)H-Index: 15
Last. Guoping Feng (MIT: Massachusetts Institute of Technology)H-Index: 80
view all 10 authors...
Summary Searching for factors to improve knockin efficiency for therapeutic applications, biotechnology, and generation of non-human primate models of disease, we found that the strand exchange protein RAD51 can significantly increase Cas9-mediated homozygous knockin in mouse embryos through an interhomolog repair (IHR) mechanism. IHR is a hallmark of meiosis but only occurs at low frequencies in somatic cells, and its occurrence in zygotes is controversial. Using multiple approaches, we provide...
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#1J. Maximilian Fels (Albert Einstein College of Medicine)H-Index: 9
#2Daniel P. MaurerH-Index: 4
Last. Kartik Chandran (Albert Einstein College of Medicine)H-Index: 75
view all 29 authors...
Crimean-Congo hemorrhagic fever virus (CCHFV) is a World Health Organization priority pathogen. CCHFV infections cause a highly lethal hemorrhagic fever for which specific treatments and vaccines are urgently needed. Here, we characterize the human immune response to natural CCHFV infection to identify potent neutralizing monoclonal antibodies (nAbs) targeting the viral glycoprotein. Competition experiments showed that these nAbs bind six distinct antigenic sites in the Gc subunit. These sites w...
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#1Evangelos Giampazolias (Francis Crick Institute)H-Index: 2
#2Oliver Schulz (Francis Crick Institute)H-Index: 30
Last. Caetano Reis e Sousa (Francis Crick Institute)H-Index: 85
view all 17 authors...
Cross-presentation of antigens from dead tumor cells by type 1 conventional dendritic cells (cDC1s) is thought to underlie priming of anti-cancer CD8+ T cells. cDC1 express high levels of DNGR-1 (a.k.a. CLEC9A), a receptor that binds to F-actin exposed by dead cell debris and promotes cross-presentation of associated antigens. Here, we show that secreted gelsolin (sGSN), an extracellular protein, decreases DNGR-1 binding to F-actin and cross-presentation of dead cell-associated antigens by cDC1s...
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