Contemporary Update of a Multi-Institutional Predictive Nomogram for Salvage Radiotherapy After Radical Prostatectomy

Published on Oct 23, 2016in Journal of Clinical Oncology32.956
· DOI :10.1200/JCO.2016.67.9647
Rahul D. Tendulkar21
Estimated H-index: 21
(Cleveland Clinic),
Shree Agrawal7
Estimated H-index: 7
(Case Western Reserve University)
+ 17 AuthorsAndrew J. Stephenson57
Estimated H-index: 57
(Case Western Reserve University)
PurposeWe aimed to update a previously published, multi-institutional nomogram of outcomes for salvage radiotherapy (SRT) following radical prostatectomy (RP) for prostate cancer, including patients treated in the contemporary era.MethodsIndividual data from node-negative patients with a detectable post-RP prostate-specific antigen (PSA) treated with SRT with or without concurrent androgen-deprivation therapy (ADT) were obtained from 10 academic institutions. Freedom from biochemical failure (FFBF) and distant metastases (DM) rates were estimated, and predictive nomograms were generated.ResultsOverall, 2,460 patients with a median follow-up of 5 years were included; 599 patients (24%) had a Gleason score (GS) ≤ 6, 1,387 (56%) had a GS of 7, 244 (10%) had a GS of 8, and 230 (9%) had a GS of 9 to 10. There were 1,370 patients (56%) with extraprostatic extension (EPE), 452 (18%) with seminal vesicle invasion (SVI), 1,434 (58%) with positive surgical margins, and 390 (16%) who received ADT (median, 6 months)....
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