Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity

Volume: 42, Issue: 2, Pages: 512 - 523
Published: Jul 27, 2016
Abstract
Serotonin (5-HT) deficiency occurs in a number of brain disorders that affect cognitive function. However, a direct causal relationship between 5-HT hypo-transmission and memory and underlying mechanisms has not been established. We used mice with a constitutive depletion of 5-HT brain levels (Pet1KO mice) to analyze the contribution of 5-HT to different forms of learning and memory. Pet1KO mice exhibited a striking deficit in novel object...
Paper Details
Title
Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity
Published Date
Jul 27, 2016
Volume
42
Issue
2
Pages
512 - 523
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