Original paper
TALEN-based generation of a cynomolgus monkey disease model for human microcephaly
Abstract
Gene editing in non-human primates may lead to valuable models for exploring the etiologies and therapeutic strategies of genetically based neurological disorders in humans. However, a monkey model of neurological disorders that closely mimics pathological and behavioral deficits in humans has not yet been successfully generated. Microcephalin 1 (MCPH1) is implicated in the evolution of the human brain, and MCPH1 mutation causes microcephaly...
Paper Details
Title
TALEN-based generation of a cynomolgus monkey disease model for human microcephaly
Published Date
Aug 9, 2016
Journal
Volume
26
Issue
9
Pages
1048 - 1061