Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

Human and murine tumour cells induce programmed necrosis (necroptosis) of endothelial cells, which promotes tumour cell extravasation and metastasis. A critical step in the metastatic spread of cancer is the escape of a circulating tumour cell from the blood stream across the endothelial barrier. This report identifies a novel mechanism that facilitates tumour cell extravasation. Tumour cells expressing amyloid precursor protein are shown to...