Role of cortical bone in bone fragility.

Published on Jul 1, 2015in Current Opinion in Rheumatology5.006
· DOI :10.1097/BOR.0000000000000183
Yohann Bala22
Estimated H-index: 22
(INSA Lyon: Institut national des sciences Appliquées de Lyon),
Roger Zebaze27
Estimated H-index: 27
(University of Melbourne),
Ego Seeman108
Estimated H-index: 108
(University of Melbourne)
Sources
Abstract
Purpose of reviewTrabecular bone loss and vertebral fractures are historical hallmarks of osteoporosis. During the past 70 years, this view has dominated research aiming to understand the structural basis of bone fragility. We suggest this notion needs to be revised to recognize and include the role
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Fragility fractures commonly involve metaphyses. The distal radius is assembled with a thin cortex formed by fusion (corticalization) of trabeculae arising from the periphery of the growth plate. Centrally positioned trabeculae reinforce the thin cortex and transfer loads from the joint to the proximal thicker cortical bone. We hypothesized that growth- and age-related deficits in trabecular bone disrupt this frugally assembled microarchitecture, producing bone fragility. The microarchitecture o...
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