Original paper

Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation

Volume: 24, Issue: 12, Pages: 2116 - 2125
Published: Dec 1, 2016
Abstract
Objective Type 2 Diabetes (T2D) is a risk factor for osteoarthritis (OA). Autophagy, an essential homeostasis mechanism in articular cartilage, is defective in T2D and OA. However, how T2D may influence OA progression is still unknown. We aimed to determine how diabetes affects cartilage integrity and whether pharmacological activation of autophagy has efficacy in diabetic mice (db/db mice) with OA. Design Experimental OA was performed in the...
Paper Details
Title
Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation
Published Date
Dec 1, 2016
Volume
24
Issue
12
Pages
2116 - 2125
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