SIGNAL (programming language)

Interference (communication)

Capacitance

Polymer chemistry

Biology

Biomedical engineering

Materials science

Continuous monitoring

Embedded system

Operating system

Economics

Computer science

Acoustics

Self-healing

Swelling

Computer network

Physical chemistry

Alternative medicine

Capacitive sensing

Physics

Nanotechnology

Database

Self-healing hydrogels

Electronic skin

Wearable computer

Operations management

Composite material

Measure (data warehouse)

Medicine

Chemistry

Programming language

Electrode

Channel (broadcasting)

Biological system

Optoelectronics

Pathology

Advanced Functional Materials

In both artificial electronic and ionic skins, the distinction of multi‐stimuli response in a single sensing unit is challenging, due to unavoidable mutual signal interference. Here, a zwitterionic skin sensor system that can continuously monitor and differentiate three‐stimuli‐responsive information in real‐time is designed. This sandwich‐structured sensor system is based on a zwitterionic thermo–glucose‐sensitive skin‐like hydrogel at its upper and lower layers with a middle isolation elastomer layer, enabling monitoring and distinction of temperature, mechanical and glucose information without signal interference: 1) the capacitance of the upper/lower layers as glucose–temperature‐insensitive is variable to measure strain; 2) the resistance of the upper hydrogel as glucose‐insensitive is variable to measure strain and temperature; and 3) the resistance of the lower hydrogel can detect three indicators. Based on the skin sensor system, a smart wound dressing is developed to pro‐heal chronic diabetic wounds and enable continuous real‐time monitoring of three indicators—infection, swelling, and blood glucose. This work provides a new method of real‐time monitoring and the distinction of multi‐stimuli response in a wearable device.

Pro‐Healing Zwitterionic Skin Sensor Enables Multi‐Indicator Distinction and Continuous Real‐Time Monitoring