Osteoarthritis and Cartilage
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#1Kathryn N. Culliton (Carleton University)
#2Andrew D. Speirs (Carleton University)H-Index: 11
OBJECTIVE The objectives of this study were: first, to compare solute uptake driven by sliding to cyclic uniaxial compression. And secondly, to evaluate the role of the superficial region on passive diffusion to determine if mechanical action is merely overcoming the low permeability of the superficial region or exceeding equilibrium capacity of the tissue. DESIGN Tests were performed on osteochondral plugs under two types of conditions: cyclic loading (sliding vs axial compression) and unloaded...
#1Brittany D. Partain (UF: University of Florida)H-Index: 2
#2Qingteng Zhang (Argonne National Laboratory)H-Index: 11
Last. Kyle D. Allen (UF: University of Florida)H-Index: 18
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Summary Objective Tissues have complex structures, comprised of solid and fluid phases. Improved understanding of interactions between joint fluid and extracellular matrix (ECM) is required in models of cartilage mechanics. X-ray photon correlation spectroscopy (XPCS) directly measures nanometer-scale dynamics and can provide insight into biofluid-biosolid interactions in cartilage. This study applies XPCS to evaluate dynamic interactions between intact cartilage and biofluids. Design Cartilage ...
#1Valia Leifer (Brigham and Women's Hospital)H-Index: 1
#2Jeffrey N. KatzH-Index: 129
Last. Elena LosinaH-Index: 99
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Summary Osteoarthritis (OA) is a highly prevalent and disabling condition that affects over 7% of people globally (528 million people). Prevalence levels are even higher in countries with established market economies, which have older demographic profiles and a higher prevalence of obesity, such as the US (14%). As the 15th highest cause of years lived with disability (YLDs) worldwide, the burden OA poses to individuals is substantial, characterized by pain, activity limitations, and reduced qua...
#1Carl R. Flannery (Durham University)H-Index: 27
#2Scott A. Seaman (Durham University)
Last. Richard F. Loeser (UNC: University of North Carolina at Chapel Hill)H-Index: 22
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Summary Objective Characterization of a novel human placental tissue-derived biologic, PTP-001, which is in development as a candidate therapeutic for the treatment of osteoarthritis symptoms and pathophysiology. Methods Human placental tissues from healthy donors were prepared as a particulate formulation, PTP-001. PTP-001 extracts were assayed for the presence of disease-relevant biofactors which could have beneficial effects in treating osteoarthritis. PTP-001 eluates were tested in human cho...
#1Qiang Guo (WMU: Wenzhou Medical College)H-Index: 2
#2Ding-Chao Zhu (WMU: Wenzhou Medical College)H-Index: 2
Last. Yaosen Wu (WMU: Wenzhou Medical College)H-Index: 22
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Summary Objective DNA damage induced by ROS is considered one of the main causes of nucleus pulposus (NP) cells degeneration during the progression of intervertebral disc degeneration (IVDD). cGAS-STING pathway acts as DNA-sensing mechanism for monitoring DNA damage. Recent studies have proved that cGAS-STING contributes to the development of various diseases by inducing inflammation, senescence, and apoptosis. This work explored the role of STING, the main effector of cGAS-STING signaling pathw...
#1Dennis C. Turk (UW: University of Washington)H-Index: 137
#1Matthew Pettit (University of Cambridge)
#2C. Doran (University of Cambridge)
Last. Vikas Khanduja (University of Cambridge)H-Index: 25
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Summary Objective A higher prevalence of cam morphology has been reported in the athletic population but the development of the cam morphology is not fully understood. The purpose of this systematic review is to establish the timing of development of the cam morphology in athletes, the proximal femoral morphologies associated with its development, and other associated factors. Design Embase, MEDLINE and the Cochrane Library were searched for articles related to development of the cam morphology,...
#1E. Houtman (LUMC: Leiden University Medical Center)H-Index: 3
#2Rodrigo Coutinho de Almeida (LUMC: Leiden University Medical Center)H-Index: 12
Last. Ingrid Meulenbelt (LUMC: Leiden University Medical Center)H-Index: 59
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Summary OBJECTIVE We here aimed to characterize changes of Matrix Gla Protein (MGP) expression in relation to its recently identified OA risk allele rs1800801-T in OA cartilage, subchondral bone and human ex vivo osteochondral explants subjected to OA related stimuli. Given that MGP function depends on vitamin K bioavailability, we studied the effect of frequently prescribed vitamin K antagonist warfarin. METHODS Differential (allelic) mRNA expression of MGP was analyzed using RNA-sequencing dat...
#1Huanhuan Liu (OU: Ohio University)
#2Thomas J. Rosol (OU: Ohio University)H-Index: 64
Last. Shouan Zhu (OU: Ohio University)
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Summary Objective ‘Carbon stress' is a newly found mechanism that links obesity and dysregulated metabolism. It is defined as the cellular accumulation of metabolites during obesity post-translationally modifying metabolic proteins and decreasing their enzymatic activity. The objective of this study was to investigate if ‘carbon stress' also occurs in cartilage and contributes to obesity associated OA development. Methods We histologically evaluated for OA pathology in wild-type (WT) and hyperph...
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