Osteoarthritis and Cartilage
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#1J.P.M. Vrouwe (LUMC: Leiden University Medical Center)
Last. R.G.H.H. Nelissen (LUMC: Leiden University Medical Center)H-Index: 1
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Summary null null Objective null Inflammatory hand arthritis (IHA) results in impaired function. Local gene therapy with ART-I02, a recombinant adeno-associated viral (AAV) serotype 5 vector expressing interferon(IFN)-β, under the transcriptional control of nuclear factor κ-B responsive promoter, was preclinically shown to have favorable effects. This study aimed to investigate the safety and tolerability of local gene therapy with ART-I02 in patients with IHA. null null null Method null In this...
#2Christopher B. Little (RNSH: Royal North Shore Hospital)H-Index: 60
Last. R. GosminiH-Index: 2
view all 20 authors...
Summary null Objective null A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a key enzyme in degradation of cartilage in osteoarthritis (OA). We report the pharmacological characterization of GLPG1972/S201086, a new, potent and selective small-molecule ADAMTS5 inhibitor. null Methods null Potency and selectivity of GLPG1972/S201086 for ADAMTS5 were determined using fluorescently-labeled peptide substrates. Inhibitory effects of GLPG1972/S201086 on interleukin-1α-stim...
1 CitationsSource
#1Augustin Latourte (University of Paris)H-Index: 7
#2Pascal Richette (University of Paris)H-Index: 56
#2Elizabeth Matzkin (Brigham and Women's Hospital)H-Index: 19
Last. Jeffrey N. Katz (Brigham and Women's Hospital)H-Index: 130
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Summary null null Objective null To identify and summarize literature related to the association between mechanical symptoms (catching and locking of the knee), the presence of meniscal tear, and outcomes after arthroscopic surgery. null null null Design null We searched PubMed and hand-searched reference lists for relevant articles and selected 38 for analysis. null null null Results null Mechanical symptoms appear to have modest sensitivity (ranging 0.32–0.69), specificity (ranging 0.45–0.74) ...
#1Michelle L. Hall (University of Melbourne)H-Index: 29
#2M. van der EschH-Index: 14
Last. M. de RooijH-Index: 2
view all 16 authors...
Hip and knee osteoarthritis (OA) are leading causes of global disability. Most research to date has focused on the knee, with results often extrapolated to the hip, and this extends to treatment recommendations in clinical guidelines. Extrapolating results from research on knee OA may limit our understanding of disease characteristics specific to hip OA, thereby constraining development and implementation of effective treatments. This review highlights differences between hip and knee OA with re...
#1Aileen M. Davis (UHN: University Health Network)H-Index: 83
#2R. Wong (UHN: University Health Network)H-Index: 5
Last. N. Urquhart (Dal: Dalhousie University)H-Index: 1
view all 14 authors...
Summary null null Introduction null Anterior cruciate ligament (ACL) injury is a risk factor for developing knee osteoarthritis (OA). We developed an intervention to support people manage risk factors for OA. null null null Methods null We conducted one-on-one interviews with 20 individuals with OA symptoms 6–15 years post ACL injury and used a nominal group process during a workshop with 40 patients and healthcare professionals (HCPs) to elicit information on the intervention content and delive...
#1Kaetlyn R. Arant (Brigham and Women's Hospital)H-Index: 2
#2Jeffrey N. KatzH-Index: 130
Last. Tuhina Neogi (BU: Boston University)H-Index: 66
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Summary null null Objective null This review outlines the most commonly used quantitative sensory tests to identify pain sensitization. We examine cross-sectional associations between quantitative sensory testing (QST) measures and OA symptoms and severity, along with longitudinal associations between QST findings and response to surgical and non-surgical treatments for OA. null null null Design null We conducted a search in PubMed for English language papers including ‘osteoarthritis’ and ‘quan...
1 CitationsSource
#1Patrick Omoumi (UNIL: University of Lausanne)H-Index: 22
#2Anna Schuler (UNIL: University of Lausanne)
Last. J Favre (École Polytechnique)
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Summary null Objective null To characterize the differences and correlations in osteophyte volumes between and within proximal tibial compartments, and to assess the correlations between osteophyte volumes and the femorotibial angle. null Design null CT scans of 73 knees with predominantly medial femorotibial osteoarthritis (21 K/L2, 28 K/L3, 24 K/L4) were retrospectively analyzed using a new, reproducible method measuring total and subregional osteophyte volumes in the medial and lateral compar...
#1Jackie L. Whittaker (UBC: University of British Columbia)H-Index: 23
#2Jos Runhaar (EUR: Erasmus University Rotterdam)H-Index: 17
Last. Ewa M. Roos (University of Southern Denmark)H-Index: 82
view all 4 authors...
Summary null null Prevention is an attractive solution for the staggering and increasingly unmanageable burden of osteoarthritis. Despite this, the field of osteoarthritis prevention is relatively immature. To date, most of what is known about preventing osteoarthritis and risk factors for osteoarthritis is relative to the disease (underlying biology and pathophysiology) of osteoarthritis, with few studies considering risk factors for osteoarthritis illness, the force driving the personal, finan...
1 CitationsSource
#1Frank W. Roemer (BU: Boston University)H-Index: 75
#2Ali Guermazi (BU: Boston University)H-Index: 101
Last. Richard Kijowski (NYU: New York University)H-Index: 1
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Osteoarthritis (OA) is the most frequent form of arthritis with major implications on both individual and public health care levels. The field of joint imaging, and particularly magnetic resonance imaging (MRI), has evolved rapidly due to the application of technical advances to the field of clinical research. This narrative review will provide an introduction to the different aspects of OA imaging aimed at an audience of scientists, clinicians, students, industry employees, and others who are i...
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Physical therapy