Multi-responsive magnetic microsphere of poly(N-isopropylacrylamide)/carboxymethylchitosan hydrogel for drug controlled release

Multi-responsive composite microspheres were synthesized via an in situ free radical polymerization of thermo-responsive poly(N-isopropylacrylamide) (poly(NIPAAm)) in the presence of carboxymethylchitosan (CMC) and magnetite nanoparticles (MNPs) followed by glutaraldehyde crosslinking. Formulation conditions of the composite microspheres were tuned such that spherical microspheres with narrow size distributions were obtained (30.0±1.0μm in...