IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes
Volume: 310, Issue: 11, Pages: H1611 - H1621
Published: Jun 1, 2016
Abstract
Currently available induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) do not ideally model cellular mechanisms of human arrhythmic disease due to lack of a mature action potential (AP) phenotype. In this study, we create and characterize iPS-CMs with an electrically mature AP induced by potassium inward rectifier ( I K1 ) enhancement. The advantages of I K1 -enhanced iPS-CMs include the absence of spontaneous beating, stable resting...
Paper Details
Title
IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes
Published Date
Jun 1, 2016
Volume
310
Issue
11
Pages
H1611 - H1621
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