American Journal of Physiology-heart and Circulatory Physiology
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#1Brian Hayes (UBC: University of British Columbia)H-Index: 1
#2Mary Fossey (UBC: University of British Columbia)H-Index: 1
Last. Christopher R. West (UBC: University of British Columbia)H-Index: 21
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Background: Spinal cord injury (SCI) impairs the cardiovascular responses to postural challenge, leading to the development of orthostatic hypotension (OH). Here, we apply lower body negative press...
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#1Niels T. Olsen (Copenhagen University Hospital)H-Index: 1
#1Niels Thue Olsen (UCPH: University of Copenhagen)H-Index: 14
Last. Jørn Carlsen (Copenhagen University Hospital)H-Index: 23
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Background Myocardial function and exercise reserve are important determinants of outcome in pulmonary arterial hypertension (PAH) but are incompletely understood. For this study, we performed subj...
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#1Paula Rodriguez-Miguelez (VCU: Virginia Commonwealth University)H-Index: 15
#2Jennifer S. Pollock (UAB: University of Alabama at Birmingham)H-Index: 72
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#1Mike Stembridge (Cardiff Metropolitan University)H-Index: 15
#2Ryan L. Hoiland (UBC: University of British Columbia)H-Index: 20
Last. James D. Anholm (LLU: Loma Linda University)H-Index: 13
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Haemoconcentration can influence hypoxic pulmonary vasoconstriction (HPV) via increased frictional force and vasoactive signalling from erythrocytes, but whether the balance of these mechanism is modified by the duration of hypoxia remains to be determined. We performed three sequential studies: (i) at sea level, in normoxia and isocapnic hypoxia with and without isovolumic haemodilution (n=10, aged 29±7 years); (ii) at altitude (6±2 days acclimatization at 5050 m), before and during hypervolumi...
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#1Ethan Dillon Kwan (UCSD: University of California, San Diego)
#2Daniela Vélez-Rendón (UIC: University of Illinois at Chicago)H-Index: 3
Last. Daniela Valdez-Jasso (UCSD: University of California, San Diego)H-Index: 8
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While pulmonary arterial hypertension (PAH) leads to right ventricle (RV) hypertrophy and structural remodeling, the relative contributions of changes in myocardial geometric and mechanical properties to systolic and diastolic chamber dysfunction and their time courses remain unknown. Using measurements of RV hemodynamic and morphological changes over 10 weeks in a male rat model of PAH and a mathematical model of RV mechanics, we discriminated the contributions of RV geometric remodeling and al...
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#1Antonella Cellini (University of Würzburg)H-Index: 1
#2Dorina Höfler (University of Würzburg)
Last. Petra Eder-Negrin (University of Würzburg)H-Index: 3
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Aim: The role of the Na+/K+-ATPase (NKA) in heart failure associated with myocardial infarction (MI) is poorly understood. The elucidation of its precise function is hampered by the existence of tw...
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#1Miles A. Tanner (MU: University of Missouri)H-Index: 16
#2Charles A. Maitz (MU: University of Missouri)H-Index: 4
Last. Laurel A. Grisanti (MU: University of Missouri)H-Index: 5
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β-Adrenergic receptors (βAR) regulate normal and pathophysiological heart function through their impact on contractility. βAR are also regulators of immune function where they play a unique role depending on the disease condition and immune cell type. Emerging evidence suggests an important role for the β2AR subtype in regulating remodeling in the pathological heart, however, the importance of these responses has never been examined. In heart failure, catecholamines are elevated, leading to chro...
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#1Shanna Hamilton (OSU: Ohio State University)H-Index: 8
#2Radmila Terentyeva (OSU: Ohio State University)H-Index: 21
Last. Dmitry Terentyev (OSU: Ohio State University)H-Index: 32
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Cardiac dysfunction in heart failure (HF) and diabetic cardiomyopathy (DCM) is associated with aberrant intracellular Ca2+ handling and impaired mitochondrial function accompanied with reduced mito-[Ca2+]. Pharmacological or genetic facilitation of mito-Ca2+ uptake was shown to restore Ca2+ transient amplitude in DCM and HF, improving contractility. However, recent reports suggest that pharmacological enhancement of mito-Ca2+ uptake can exacerbate ryanodine receptor-mediated spontaneous sarcopla...
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#1Irene M. Lang (Medical University of Vienna)H-Index: 61
#2Stefan Thurner (Medical University of Vienna)H-Index: 48
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