[Effect of angiotensin II receptor blocker on insulin signaling in skeletal muscle cells].

Impairment of insulin-dependent glucose uptake in skeletal muscles plays a major role in the pathogenesis of diabetes mellitus. Angiotensin converting-enzyme inhibitor (ACEI) has been demonstrated to improve insulin-sensitivity in diabetic patients, partly through the increase in peripheral blood flow mediated by either suppressed angiotensin II or elevated bradykinin. Recently, angiotensin II type-1 receptor blocker (ARB) has been shown to...