Yoshio Nakamura
Okayama University
Angiotensin receptorAngiotensin II receptor type 1Internal medicineEndocrinologySurgeryCardiologyMorningHepatocyte growth factorEssential hypertensionHemodialysisPulse wave velocityKidney diseaseProteinuriaTelmisartanDiabetic nephropathyAngiotensin IIChronic renal failureIn patientDiabetes mellitusMedicineBlood pressureGastroenterologyPharmacology
Publications 34
#1Kazutoshi MurakamiH-Index: 14
#2Jun WadaH-Index: 63
Last. Hirofumi MakinoH-Index: 98
view all 9 authors...
#1Kazutoshi Murakami (Okayama University)H-Index: 14
#2Jun Wada (Okayama University)H-Index: 63
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 9 authors...
Telmisartan partially activates the peroxisome proliferator-activated receptor γ (PPARγ), which may ameliorate the accumulation of visceral adipose tissues and sensitise insulin action. Nineteen patients with essential hypertension and metabolic syndrome were randomly assigned to receive 40 mg of telmisartan (TELMI group) once daily or 80 mg of valsartan (VAL group) once daily for 24 weeks. The visceral fat area (VFA) measured by computed tomography (CT) was significantly reduced from 150.4±15.5...
18 CitationsSource
#1Yoshihisa HanayamaH-Index: 6
#2Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 4 authors...
�������������������������������������� ������������-����� ������ Angiotensin receptor blockers (ARBs are the first‑line antihypertensive agents. In clinical practice it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood pressure (MHBP in comparison to high‑dose ARB therapy in patients with morning hypertension admini...
5 CitationsSource
#1Haruhito A. UchidaH-Index: 15
#2Yoshio Nakamura (Okayama University)H-Index: 12
Last. Hirofumi MakinoH-Index: 98
view all 9 authors...
Aims/Introduction: The combination of hypertension with diabetes mellitus (DM) has been recognized as a critical risk factor for cardiovascular disease (CVD). We investigated the blood pressure levels in hypertensive patients with DM (HDM patients) compared with those without DM (HnDM patients). Furthermore, we examined the effect of risk factors, including chronic kidney disease (CKD) and stroke, on the management of both office blood pressure (OBP) and morning home blood pressure (MHBP). Mater...
#1Masanobu Kaihara (Okayama University)H-Index: 5
#2Yoshio Nakamura (Okayama University)H-Index: 12
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 7 authors...
We investigated the impact of olmesartan and temocapril on pancreatic islet beta-cells during the development of diabetes mellitus using Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats. Four-week-old male OLETF rats were fed standard chow (untreated:n5), or chow containing either 0.005% olmesartan(n5) or 0.01% temocapril (n5) until being sacrificed at 35 weeks of age. Pancreas sections were double-stained with anti-insulin and anti-glucagon antibodies. The percent areas of beta-cells, alpha-cells...
9 CitationsSource
#1Yayoi Emi (RMIT: RMIT University)H-Index: 3
#2Miwa Adachi (Okayama University)H-Index: 2
Last. Mikiya Nakatsuka (RMIT: RMIT University)H-Index: 7
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Aim: Female-to-male (FTM) transsexuals are treated with long-term and high-dose androgen. Although androgen is known to affect the cardiovascular system, vascular function in FTM transsexuals has not been fully elucidated. The aim of this study was to evaluate the arterial stiffness in FTM transsexuals treated with androgen. Methods: We evaluated the arterial stiffness in 111 FTM transsexuals (63 untreated FTM transsexuals and 48 FTM transsexuals treated with androgen) using a volume-plethysmogr...
23 CitationsSource
#1Haruhito Uchida (Okayama University)H-Index: 3
#2Yoshio Nakamura (Okayama University)H-Index: 12
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 6 authors...
The MUSCAT Study: A Multicenter PROBE Study Comparing the Effects of Angiotensin II Type-1 Receptor Blockers on Self-Monitored Home Blood Pressure in Patients with Morning Hypertension: Study Design and Background Characteristics
7 CitationsSource
#1Haruhito A. Uchida (Okayama University)H-Index: 15
#2Yoshio Nakamura (Okayama University)H-Index: 12
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 9 authors...
Background. Decreased plasma adiponectin is associated with impaired endothelial function and, thereby, increased risk for cardiovascular events. Glucocorticoid (GC) affects vascular endothelial cells either favourably or harmfully depending upon the dosages and duration. We examined the effect of GC pulse therapy on vascular endothelial function. Methods. Fourteen young patients with IgA nephropathy were evaluated for flow-mediated vasodilation (FMD), plasma levels of adiponectin both in high m...
28 CitationsSource
#1Yoshio Nakamura (Okayama University)H-Index: 12
#2Hirofumi Makino (Okayama University)H-Index: 98
2 CitationsSource
#1Mie Maruyama (Okayama University)H-Index: 5
#2Yasushi Yamasaki (Okayama University)H-Index: 25
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 9 authors...
A 22-year-old woman hospitalized for polyarthralgia was diagnosed with systemic lupus erythematosus (SLE). She was treated with prednisolone, and her clinical manifestations improved. However, she was re-admitted for renal biopsy because of persistent hypocomplementemia and development of proteinuria. The biopsy revealed segmental spike formation of basement membrane and subepithelial immune complex deposition, and membranous lupus nephritis (class V) was diagnosed. When tacrolimus was added to ...
16 CitationsSource