Masanobu Kaihara
Okayama University
Angiotensin receptorInsulin receptorVasodilationAngiotensin II receptor type 1Internal medicineEndocrinologySurgerySurrogate endpointInsulin-like growth factor 1 receptorOdds ratioCardiologyIsletIntensive care medicineMorningRenin–angiotensin systemAdiponectinTemocaprilHepatocyte growth factorEssential hypertensionValsartanPulse wave velocityKidney diseasePancreasInsulinBradykininTelmisartanOlmesartanPancreatic isletsAsymmetric dimethylarginineUric acidCandesartanLosartanGlucocorticoidEndothelial dysfunctionNephropathyAngiotensin IIType 2 Diabetes MellitusIn patientLong evansRisk factorStrokeDiabetes mellitusDiastoleMedicineBlood pressurePharmacology
7Publications
5H-index
88Citations
Publications 7
Newest
#1Haruhito A. UchidaH-Index: 15
#2Yoshio Nakamura (Okayama University)H-Index: 12
Last. Hirofumi MakinoH-Index: 98
view all 9 authors...
Aims/Introduction: The combination of hypertension with diabetes mellitus (DM) has been recognized as a critical risk factor for cardiovascular disease (CVD). We investigated the blood pressure levels in hypertensive patients with DM (HDM patients) compared with those without DM (HnDM patients). Furthermore, we examined the effect of risk factors, including chronic kidney disease (CKD) and stroke, on the management of both office blood pressure (OBP) and morning home blood pressure (MHBP). Mater...
Source
#1Masanobu Kaihara (Okayama University)H-Index: 5
#2Yoshio Nakamura (Okayama University)H-Index: 12
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 7 authors...
We investigated the impact of olmesartan and temocapril on pancreatic islet beta-cells during the development of diabetes mellitus using Otsuka-Long-Evans-Tokushima Fatty (OLETF) rats. Four-week-old male OLETF rats were fed standard chow (untreated:n5), or chow containing either 0.005% olmesartan(n5) or 0.01% temocapril (n5) until being sacrificed at 35 weeks of age. Pancreas sections were double-stained with anti-insulin and anti-glucagon antibodies. The percent areas of beta-cells, alpha-cells...
9 CitationsSource
#1Haruhito Uchida (Okayama University)H-Index: 3
#2Yoshio Nakamura (Okayama University)H-Index: 12
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 6 authors...
The MUSCAT Study: A Multicenter PROBE Study Comparing the Effects of Angiotensin II Type-1 Receptor Blockers on Self-Monitored Home Blood Pressure in Patients with Morning Hypertension: Study Design and Background Characteristics
7 CitationsSource
#1Haruhito A. Uchida (Okayama University)H-Index: 15
#2Yoshio Nakamura (Okayama University)H-Index: 12
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 9 authors...
Background. Decreased plasma adiponectin is associated with impaired endothelial function and, thereby, increased risk for cardiovascular events. Glucocorticoid (GC) affects vascular endothelial cells either favourably or harmfully depending upon the dosages and duration. We examined the effect of GC pulse therapy on vascular endothelial function. Methods. Fourteen young patients with IgA nephropathy were evaluated for flow-mediated vasodilation (FMD), plasma levels of adiponectin both in high m...
28 CitationsSource
#1Haruhito A. UchidaH-Index: 15
#2Yoshio NakamuraH-Index: 12
Last. Hirofumi MakinoH-Index: 98
view all 8 authors...
#1Haruhito Uchida (Okayama University)H-Index: 3
#1Haruhito A. Uchida (Okayama University)H-Index: 15
Last. Hirofumi Makino (Okayama University)H-Index: 98
view all 8 authors...
The current guideline-recommended blood pressure values are difficult to maintain in general practice, partly due to the lack of ideal anti-hypertensive agents. Since morning hypertension has a high correlation with cardiovascular events, expectations that telmisartan, a long-acting angiotensin-II type-1 receptor blocker (ARB), can improve cardiovascular mortality are high. In this study, the efficiency of telmisartan in reducing morning hypertension and pulse wave velocity (PWV) as a practical ...
58 CitationsSource
#1Masanobu Kaihara (Okayama University)H-Index: 5
#2Yoshio NakamuraH-Index: 12
Last. Hirofumi MakinoH-Index: 98
view all 3 authors...
: Impairment of insulin-dependent glucose uptake in skeletal muscles plays a major role in the pathogenesis of diabetes mellitus. Angiotensin converting-enzyme inhibitor (ACEI) has been demonstrated to improve insulin-sensitivity in diabetic patients, partly through the increase in peripheral blood flow mediated by either suppressed angiotensin II or elevated bradykinin. Recently, angiotensin II type-1 receptor blocker (ARB) has been shown to produce similar effects, postulating the importance o...
5 Citations