Parenteral MCT/ω-3 Polyunsaturated Fatty Acid-Enriched Intravenous Fat Emulsion Is Associated With Cytokine and Fatty Acid Profiles Consistent With Attenuated Inflammatory Response in Preterm Neonates: A Randomized, Double-Blind Clinical Trial.

Published on Apr 1, 2016in Nutrition in Clinical Practice3.08
· DOI :10.1177/0884533615602011
Maria Skouroliakou16
Estimated H-index: 16
(HUA: Harokopio University),
Dimitris Konstantinou4
Estimated H-index: 4
+ 6 AuthorsThomais Karagiozoglou-Lampoudi10
Estimated H-index: 10
Sources
Abstract
Background: Soybean oil–based intravenous fat emulsion (IVFE) administered to preterm neonates can induce oxidative stress and inflammatory response, which are associated with severe complications of prematurity. This study aimed to test the hypothesis that administration of medium-chain triglyceride (MCT)/ω-3 polyunsaturated fatty acid (PUFA)–enriched IVFE in preterm neonates is associated with a cytokine and fatty acid (FA) profile consistent with attenuated inflammatory response. Patients/Methods: In a double-blind randomized study, 60 preterm neonates (gestational age 26–32 weeks) were randomized to receive either MCT/ω-3 PUFA-enriched IVFE (intervention group) or soybean oil–based IVFE (control group). Serum biochemistry, tumor necrosis factor (TNF)–α, interleukin (IL)–6, IL-8, α-tocopherol, and FAs were assessed at baseline, on day of life 15, and day of life 30 or at the end of intervention. Results: All cytokine levels changed significantly across the 3 time points, whereas the type of IVFE had a ...
📖 Papers frequently viewed together
References60
Newest
#1Bodil M. K. Larsen (AHS: Alberta Health Services)H-Index: 8
#2Catherine J. Field (U of A: University of Alberta)H-Index: 73
Last. Michael T. Clandinin (U of A: University of Alberta)H-Index: 56
view all 7 authors...
Background: The effect of providing a lipid emulsion containing medium-chain triglyceride (MCT), soybean oil, and fish oil in critically ill infants is not widely studied. This study investigated lipid emulsion effects on plasma phospholipids and immune biomarkers. Materials and Methods: Thirty-two infants undergoing cardiopulmonary bypass (CPB) and dependent on parenteral nutrition (PN) were randomized to receive either soybean oil (control, n = 16) or a 50:40:10 mixture of MCT, soybean oil, an...
Source
#2Danilo Figueiredo Soave (USP: University of São Paulo)H-Index: 10
Last. Mara Rúbia Nunes Celes (USP: University of São Paulo)H-Index: 15
view all 9 authors...
Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators...
Source
#1Judith Pichler (Medical University of Vienna)H-Index: 11
#2Venetia Simchowitz (Great Ormond Street Hospital for Children NHS Foundation Trust)H-Index: 13
Last. Susan Hill (Great Ormond Street Hospital for Children NHS Foundation Trust)H-Index: 21
view all 4 authors...
Comparison of liver function with two new/mixed intravenous lipid emulsions in children with intestinal failure
Source
#1Anderson Silva Machado (UFMG: Universidade Federal de Minas Gerais)H-Index: 5
#2Ana Carolina Aguiar Vasconcelos Carneiro (UFMG: Universidade Federal de Minas Gerais)H-Index: 14
Last. Olindo Assis Martins-Filho (FIOCRUZ: Oswaldo Cruz Foundation)H-Index: 57
view all 11 authors...
Toxoplasma gondii is the main infectious cause of human posterior retinochoroiditis, the most frequent clinical manifestation of congenital toxoplasmosis. This investigation was performed after neonatal screening to identify biomarkers of immunity associated with immunopathological features of the disease by flow cytometry. The study included infected infants without NRL and with retinochoroidal lesions (ARL, ACRL, and CRL) as well as noninfected individuals (NI). Our data demonstrated that leuk...
Source
#1Ming-Hsun Wu (NTU: National Taiwan University)H-Index: 17
#2Ming-Yang Wang (NTU: National Taiwan University)H-Index: 24
Last. Ming-Tsan Lin (NTU: National Taiwan University)H-Index: 46
view all 5 authors...
Background: SMOFlipid 20% is intravenous lipid emulsion (ILE) containing long-chain triglycerides (LCT), medium-chain triglycerides (MCT), olive oil, and fish oil as a mixed emulsion containing α-tocopherol. The aim was to assess the efficacy of this new ILE in gastrointestinal surgery compared with MCT/LCT. Methods: In this prospective study, 40 patients were randomized to SMOFlipid 20% or MCT/LCT (Lipovenoes 20%) group. Clinical and biochemistry data were collected. Inflammatory markers (CRP, ...
Source
#1Michael A. Zulyniak (U of G: University of Guelph)H-Index: 14
#2Maude Perreault (U of G: University of Guelph)H-Index: 8
Last. David M. Mutch (U of G: University of Guelph)H-Index: 34
view all 5 authors...
Objective Increasing omega-3 fatty acid (FA) intake, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is associated with numerous health benefits; however, the benefits on inflammation appear to vary depending on the study population examined. While improvements in inflammatory status have been reported in the elderly, there is less evidence regarding the effects of fish oil supplementation on inflammation in young adults. The goal of the present study was to examine the ...
Source
#1Stanislaw Klek (Jagiellonian University Medical College)H-Index: 27
#2Cécile ChambrierH-Index: 17
Last. Jon Shaffer (Salford Royal NHS Foundation Trust)H-Index: 21
view all 14 authors...
Summary Precis The aim of this study was to evaluate the safety and tolerance of a soybean/MCT/olive/fish oil emulsion in intestinal failure patients on long-term parenteral nutrition. 73 patients took part in a randomized, double-blind, multi-centre study. The study demonstrates that the lipid emulsion containing four different types of oils is safe and well tolerated in long-term PN. Background & aim Long-term safety and efficacy of a lipid emulsion containing soybean oil, medium-chain triglyc...
Source
#1S Lusyati (UMCG: University Medical Center Groningen)H-Index: 1
Last. Pieter J. J. Sauer (UMCG: University Medical Center Groningen)H-Index: 36
view all 5 authors...
BACKGROUND: Cytokines might be helpful to diagnose late onset sepsis (LOS) in newborn infants. Many studies on cytokines did not discriminate culture-proven from clinically-suspected sepsis; however, such differentiation is clinically useful. OBJECTIVES: To evaluate the feasibility to differentiate among culture-proven LOS, clinical LOS and controls using a battery of cytokines. STUDY DESIGN: This prospective study was conducted at the NICU of Harapan-Kita Women and Children's Hospital, Jakarta-...
Source
#1Maria Skouroliakou (HUA: Harokopio University)H-Index: 16
view all 7 authors...
Background: This study aimed to compare the effect of 2 lipid emulsions (LEs), a medium-chain triglyceride (MCT)/ω-3–polyunsaturated fatty acid (PUFA)–containing LE and a soybean-based LE, on the incidence of neonatal cholestasis, bronchopulmonary dysplasia (BPD), and lipid profile of preterm infants. Patients and Methods: In this prospective, observational study, 2 groups of preterm neonates, the very low birth weight (VLBW) (n = 129) and the low birth weight (LBW) groups (n = 153), which recei...
Source
#1Gamze DemirelH-Index: 15
#2Serife Suna OguzH-Index: 23
Last. Ugur DilmenH-Index: 33
view all 6 authors...
article i nfo Objective: To compare the effects of two different lipid emulsions, based on soybean oil and olive oil respec- tively on plasma lipid concentrations and acylcarnitine profile of very low birth weight infants. Design: Randomized comparative study. Patients and methods: Forty very low birth weight infants, ≤32 weeks of gestational age and receiving at least 40% of the calorie taken by parenteral nutrition from lipid solution at 14th day of life were evaluated. Group I (n=20) received...
Source
Cited By30
Newest
#1Kathleen M. Gura (Boston Children's Hospital)H-Index: 39
#2Kara L. Calkins (UCLA: University of California, Los Angeles)H-Index: 11
Last. Mark Puder (Boston Children's Hospital)H-Index: 53
view all 4 authors...
OBJECTIVE To compare extrahepatic adverse events during fish oil lipid emulsion (FOLE) or soybean oil lipid emulsion (SOLE) treatment in children with intestinal failure-associated liver disease (IFALD). STUDY DESIGN In this multicenter integrated analysis, bleeding, bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), infections, and signs of lipid emulsion intolerance were compared between FOLE recipients (1 g/kg/d) (n = 189) and historical controls who received SOLE (≤3 g/kg/d)...
Source
#1Olivier Goulet (Necker-Enfants Malades Hospital)H-Index: 50
#2Antonin Lamaziere (University of Paris)H-Index: 18
Last. Cécile Lambe (Necker-Enfants Malades Hospital)H-Index: 8
view all 6 authors...
BACKGROUND Composite lipid emulsions containing soybean oil (30%), medium-chain triglycerides (30%), olive oil (25%), and fish oil (15%) (SMOF) are now widely used. OBJECTIVES We aimed to evaluate the tolerance, the efficiency, and the erythrocyte fatty acid (FA) profile for children on long-term home parenteral nutrition (HPN) receiving a composite fish oil-based emulsion (FOLE). METHODS At baseline, children (n = 46) with severe intestinal failure highly dependent on parenteral nutrition (PN) ...
Source
#1Dina Khaled Abou El Fadl (Future University in Egypt)
#2Marwa Adel Ahmed (Ain Shams University)H-Index: 1
Last. Nagwa Ali Sabri (Ain Shams University)H-Index: 9
view all 5 authors...
Abstract null null Introduction null Preterm neonates have under-developed immune-regulatory system; consequently, there is a risk for developing chronic inflammation. Necrotizing enterocolitis (NEC) is an acute devastating neonatal intestinal inflammatory disorder. Due to the obscure multifactorial etiology, early diagnosis and effective treatment of NEC are limited. Consequently, effective strategies in the prevention of NEC, including nutritional approaches, are critically needed. The current...
Source
#1Susannah FrancoH-Index: 1
#2Pavel Goriacko (Montefiore Medical Center)H-Index: 3
Last. Toshiba Morgan-Joseph (Montefiore Medical Center)H-Index: 1
view all 4 authors...
Background Parenteral nutrition (PN) is crucial for the improvement of long-term outcomes in very low birth weight (VLBW) neonates. Lipid injectable emulsions are a key component of PN, as they contain essential fatty acids and provide energy critical for brain growth. Prolonged administration increases risk of intestinal failure-associated liver disease, including cholestasis, and other complications. Methods This is a retrospective, quasi-experimental cohort study of 215 VLBW neonates. The pri...
Source
#1Katherine M. Ottolini (USU: Uniformed Services University of the Health Sciences)H-Index: 3
#2Nickie AndescavageH-Index: 14
Last. Catherine LimperopoulosH-Index: 35
view all 3 authors...
Preterm infants are born before the critical period of lipid accretion and brain development that occurs during the third trimester of pregnancy. Dietary lipids serve as an important source of energy and are involved in complex processes that are essential for normal central nervous system development. In addition to traditional neurodevelopmental testing, novel quantitative magnetic resonance imaging (MRI) techniques are now available to evaluate the impact of nutritional interventions on early...
Source
#1Katie Huff (IU: Indiana University)H-Index: 1
#2Francine D. Breckler (Riley Hospital for Children)H-Index: 11
Last. Charles Vanderpool (IU: Indiana University)H-Index: 2
view all 5 authors...
BACKGROUND Intestinal failure associated liver disease (IFALD) occurs in up to 85% of neonates on prolonged parenteral nutrition. Strategies for treatment of IFALD include alternative lipid therapies such as Smoflipid® (Fresenius Kabi). In this study we reviewed our institutional Smoflipid use including predictors of patient response and safety concerns. METHODS This is a retrospective chart review of all pediatric patients who received Smoflipid therapy over a two-year period at Riley Hospital ...
Source
#7Yvon Carpentier (ULB: Université libre de Bruxelles)H-Index: 42
Summary Background and Aims Medium-chain triglycerides (TG) (MCT) and fish oil (FO) TG are incorporated as the core TG component into intravenous (IV) lipid emulsions for infusion in parenteral nutrition. Bolus injections of IV emulsions, on the other hand, have emerged as a novel therapeutic approach to treat various acute disorders. However, intravascular metabolism and organ delivery of acute IV injection of emulsions containing both MCT and FO are not fully defined, nor have they been charac...
Source
#1Gregory Guthrie (BCM: Baylor College of Medicine)H-Index: 6
#2Douglas G. Burrin (BCM: Baylor College of Medicine)H-Index: 71
Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of l...
Source
#1Lauren C. Frazer (Boston Children's Hospital)H-Index: 11
#2Camilia R. Martin (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 26
Parenteral lipid emulsions are a necessary component of nutrition for extremely low gestational age newborns until adequate levels of enteral intake are established. Historically, Intralipid, a 100% soybean oil emulsion, has filled this role. Newer multicomponent lipid emulsions containing a mixture of other oils, including olive oil and fish oil, are now available as options, although the regulatory approval for use in neonates varies worldwide. When dosed at currently published recommendations...
Source
#1Roya Kelishadi (IUMS: Isfahan University of Medical Sciences)H-Index: 86
#2Behzad Barekatain (IUMS: Isfahan University of Medical Sciences)H-Index: 5
Last. Atefeh Fatahi (IUMS: Isfahan University of Medical Sciences)
view all 3 authors...
Background Deficiency or reduced transmission of long-chain fatty acids and essential fatty acids may inhibit lung growth and development. We aimed to evaluate and compare serum triglyceride and cholesterol levels in premature neonates with RDS. Methods This study is a cross-sectional study performed on premature neonates born in Beheshti Hospital in Isfahan in 2018. Immediately after birth and after umbilical cord clumping, blood samples were taken from the umbilical artery and triglyceride and...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.