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doi.org/10.1038/cddis.2015.233

Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4–CXCR7

..., Meinrad Gawaz
82
Cell Death and Disease
Volume: 6, Issue: 11, Pages: e1989 - e1989
Published: Nov 19, 2015
Abstract
Platelets store and release CXCL12 (SDF-1), which governs differentiation of hematopoietic progenitors into either endothelial or macrophage-foam cells. CXCL12 ligates CXCR4 and CXCR7 and regulates monocyte/macrophage functions. This study deciphers the relative contribution of CXCR4–CXCR7 in mediating the effects of platelet-derived CXCL12 on monocyte function, survival, and differentiation. CXCL12 and macrophage migration inhibitory factor...
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Paper Details
Title
Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4–CXCR7
DOI
doi.org/10.1038/cddis.2015.233
Published Date
Nov 19, 2015
Journal
Cell Death and Disease
Volume
6
Issue
11
Pages
e1989 - e1989
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