Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders
Abstract
Proper neuronal function requires tight control of gene dosage, and failure of this process underlies the pathogenesis of multiple neuropsychiatric disorders. The SHANK3 gene encoding core scaffolding proteins at glutamatergic postsynapse is a typical dosage-sensitive gene, both deletions and duplications of which are associated with Phelan-McDermid syndrome, autism spectrum disorders, bipolar disorder, intellectual disability, or schizophrenia....
Paper Details
Title
Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders
Published Date
Nov 16, 2015
Journal
Volume
8
Issue
1
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