Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders.

Published on Nov 16, 2015in Molecular Brain4.686
· DOI :10.1186/S13041-015-0165-3
Su Yeon Choi5
Estimated H-index: 5
Kaifang Pang10
Estimated H-index: 10
(BCM: Baylor College of Medicine)
+ 7 AuthorsKihoon Han17
Estimated H-index: 17
(KU: Korea University)
Background Proper neuronal function requires tight control of gene dosage, and failure of this process underlies the pathogenesis of multiple neuropsychiatric disorders. The SHANK3 gene encoding core scaffolding proteins at glutamatergic postsynapse is a typical dosage-sensitive gene, both deletions and duplications of which are associated with Phelan-McDermid syndrome, autism spectrum disorders, bipolar disorder, intellectual disability, or schizophrenia. However, the regulatory mechanism of SHANK3 expression in neurons itself is poorly understood.
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