Su Yeon Choi
KAIST
Excitatory postsynaptic potentialSynapseElectronicsmicroRNAPsychologyComposite materialCell adhesion moleculeNeuroscienceReceptorHEK 293 cellsDendritic spinePost-transcriptional regulationElectrophysiologyMaterials scienceNeurotransmissionAutismThree prime untranslated regionLong-term potentiationBipolar disorderDentate gyrusAdipateMood disordersEpilepsyPolybutyleneCYFIP2MemantineKIRREL3Major depressive disorderLubricantHippocampusPrefrontal cortexStretchable electronicsSHANK3 GeneRegulatory PathwaySynaptic signalingPostsynapseConductive pasteOxygen reductionActin cytoskeletonInhibitory synapsesFilamentous actinTransient (oscillation)Metabotropic glutamate receptor 5Chemical engineeringMorris water navigation taskMolybdenumGene dosageNMDA receptorHaploinsufficiencyMedicineNanowirePotassium channelBiologyImmunoglobulin superfamilySynaptic plasticity
8Publications
5H-index
280Citations
Publications 8
Newest
#1Su Yeon Choi (KAIST)H-Index: 5
#2Youngtae Park (KAIST)H-Index: 3
Last. Hyuck Mo Lee (KAIST)H-Index: 49
view all 9 authors...
Source
#1Kyung‐Sub Kim (SNU: Seoul National University)H-Index: 1
#2Jae-Young Yoo (KAIST)H-Index: 6
Last. Seung-Kyun Kang (SNU: Seoul National University)H-Index: 33
view all 9 authors...
Source
#1Seung-Hyun Lee (SNU: Seoul National University)H-Index: 13
#2Yinhua Zhang (KU: Korea University)H-Index: 9
Last. Kihoon Han (KU: Korea University)H-Index: 17
view all 28 authors...
OBJECTIVE Genetic variants of the cytoplasmic FMR1-interacting protein 2 (CYFIP2) encoding an actin-regulatory protein are associated with brain disorders, including intellectual disability and epilepsy. However, specific in vivo neuronal defects and potential treatments for CYFIP2-associated brain disorders remain largely unknown. Here, we characterized Cyfip2 heterozygous (Cyfip2+/- ) mice to understand their neurobehavioral phenotypes and underlying pathological mechanisms. Furthermore, we ex...
2 CitationsSource
#1Su Yeon Choi (KAIST)H-Index: 5
#2Kaifang Pang (BCM: Baylor College of Medicine)H-Index: 10
Last. Kihoon Han (KU: Korea University)H-Index: 17
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Background Proper neuronal function requires tight control of gene dosage, and failure of this process underlies the pathogenesis of multiple neuropsychiatric disorders. The SHANK3 gene encoding core scaffolding proteins at glutamatergic postsynapse is a typical dosage-sensitive gene, both deletions and duplications of which are associated with Phelan-McDermid syndrome, autism spectrum disorders, bipolar disorder, intellectual disability, or schizophrenia. However, the regulatory mechanism of SH...
39 CitationsSource
#1Su Yeon Choi (KAIST)H-Index: 5
#2Kihoon Han (KU: Korea University)H-Index: 17
Mood disorders, broadly classified as major depressive disorder and bipolar disorder, are the most common and costly psychiatric disorders worldwide. The complexity and heterogeneity of mood disorders are challenges to the progress of our understanding of the pathophysiology and the development of efficient diagnostic and therapeutic approaches. Nevertheless, recent preclinical and clinical studies have provided evidence that structural and functional alterations of neuronal excitatory synapses ...
9 CitationsSource
#1Su Yeon Choi (KAIST)H-Index: 5
#2Kihoon Han (KU: Korea University)H-Index: 17
Last. Eunjoon Kim (KAIST)H-Index: 73
view all 11 authors...
Synaptic adhesion molecules regulate diverse aspects of neuronal synapse development, including synapse specificity, formation, and maturation. Neph2, also known as Kirrel3, is an immunoglobulin superfamily adhesion molecule implicated in intellectual disability, neurocognitive delay associated with Jacobsen syndrome, and autism spectrum disorders. We here report mice lacking Neph2 (Neph2–/– mice) display moderate hyperactivity in a familiar but not novel environment and novel object recognition...
17 CitationsSource
#1Woosuk Chung (KAIST)H-Index: 11
#2Su Yeon Choi (KAIST)H-Index: 5
Last. Eunjoon Kim (KAIST)H-Index: 73
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Enhanced NMDA receptor function and social interaction deficits are observed in mice lacking the excitatory postsynaptic scaffolding protein IRSp53. Reducing NMDAR activity by pharmacological methods rescues the impaired social interaction observed in these mice. This suggests that enhanced NMDA receptor function may be associated with social deficits.
101 CitationsSource
#1Eun-Jae Lee (KAIST)H-Index: 15
#2Su Yeon Choi (KAIST)H-Index: 5
Last. Eunjoon Kim (KAIST)H-Index: 73
view all 3 authors...
Abnormalities and imbalances in neuronal excitatory and inhibitory synapses have been implicated in diverse neuropsychiatric disorders including autism spectrum disorders (ASDs). Increasing evidence indicates that dysfunction of NMDA receptors (NMDARs) at excitatory synapses is associated with ASDs. In support of this, human ASD-associated genetic variations are found in genes encoding NMDAR subunits. Pharmacological enhancement or suppression of NMDAR function ameliorates ASD symptoms in humans...
102 CitationsSource